Unraveling Germline Mutations: Advances in Genetic Profiling for Cancer Risk

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BRIEF RESEARCH REPORT

Published on 15 Oct 2025

A rare subtype of lynch syndrome familial with co-mutation of EpCAM c.344T>C, MSH2 c.2744A>G, PMS2 c.1408C>T and APC c.5465T>A, case report and literature review

Guiyu Lu
Ting Pan
Cuidong Deng
Xiaoqian Wan
Zihan Wang
Tengyue Hu
Xianshuo Cheng
Jian Dong

doi 10.3389/fgene.2025.1667899

1,749 views

ORIGINAL RESEARCH

Published on 22 Sep 2025

Next-generation sequencing of mitochondrial DNA reveals pathogenic variants and protective haplogroup D4 in esophageal cancer

Xiucheng Jiang
Lan Shi
Mei Zhao
Cui Chen
Tao Tang
Simeng Ji
Bingbing Lv
Lihua Jia
Shuhan Duan
4 more
Junbao Yang

doi 10.3389/fgene.2025.1643229

1,827 views

ORIGINAL RESEARCH

Published on 09 Sep 2025

Genetic heterogeneity in childhood leukemia/lymphoma: a Turkish cohort with strong predisposition

Gizem Onder
Ozkan Ozdemir
Fulya Taylan
Cengiz Canpolat
Koray Yalcin
Fatih Erbey
Banu Oflaz Sozmen
Fikret Asarcikli
Turan Bayhan
22 more
Ozden Hatirnaz Ng

doi 10.3389/fgene.2025.1624306

3,345 views

ORIGINAL RESEARCH

Published on 25 Jul 2025

Genetic counseling for hereditary cancer syndromes: a 5-year experience from a single center in Bulgaria

Mari Hachmeriyan
Mariya Levkova
Dinnar Yahya
Milena Stoyanova
Eleonora Dimitrova

doi 10.3389/or.2025.1605606

1,234 views

SYSTEMATIC REVIEW

Published on 16 Jul 2025

Association between the PSCA rs2976392 polymorphism and susceptibility to gastric cancer: a meta-analysis

Xiao-Hua Lin
Da-Jun Chen
Li-Juan Wang
Xiu-Ping Wan

doi 10.3389/fgene.2025.1618597

1,656 views

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