REVIEW article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
This article is part of the Research TopicThe Role of Multi-Omics Approaches in Advancing Cancer Research and Precision OncologyView all 3 articles
Applications and challenges of multi-omics approaches in lung cancer research and precision treatment
Provisionally accepted
- 1West China Hospital, Sichuan University, Chengdu, China
- 2Sichuan University West China Hospital Department of Respiratory and Critical Care Medicine, Chengdu, China
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Lung cancer is one of the most common cancers worldwide and one of the leading causes of cancer death, with a heavy disease burden and severe public health challenges. Multi-omics techniques, such as genomics, proteomics, metabolomics, and radiomics, play a crucial role in the early diagnosis and treatment of lung cancer, revealing the molecular characteristics and mechanisms of lung cancer, and have significant clinical application value. However, it also faces numerous challenges, such as data issues, "black box" problems, and ethical and legal concerns. How to leverage strengths while mitigating weaknesses, achieve clinical translation of technology, and serve patients more effectively deserves our deep reflection. This article reviews the specific applications and challenges of multi-omics methods in lung cancer research and personalized treatment.
Keywords: applications, Challenges, lung cancer, multi-omics, precision medicine
Received: 10 Oct 2025; Accepted: 29 Dec 2025.
Copyright: © 2025 Zhang, Gan, Zheng, Xu, Chen and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Bojiang Chen
Weimin Li
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