Molecular Mediators of Motion: RNA-RBP Networks in Exercise-Induced Osteoarthritis Protection

Yupeng YangXue WangXuchang ZhouYing LiYinghao ShenZhujun MaoJunjie Liu^*Zheng Mi^*

• Harbin Sport University, Harbin, China

Osteoarthritis (OA) is a relatively common chronic degenerative disease of joints which was originally considered as an imbalance between mechanical loads and tissue repair. Emerging evidence indicates that exercise confers protection not merely through mechanical loading, but by acting as a systemic regulator of RNA metabolism. This modulation mainly happens by regulating RNA–RNA-binding proteininteraction networks which have the ability to regulate joint homeostasis and delay OA process. This is a reviewed record of current study results - physical activity altered network of RNA - RBPs in different joint's related tissue such as cartilage, synovium, skeletal muscle, systemic circulation, thus changed metabolic and inflammatory pathway necessary for the joint health. Also examine molecular mechanisms by which exercise induces RNA metabolism reprogramming and protection from OA. Moreover, it also studies the promising prospects of RNA-RBP networks in early detection of OA and targeting innovative treatment strategies. By combining what we know about RNA-RBP interaction with exercise physiology, this big picture is hoping to clear the way to personalized exercise interventions, and novel RNA-targeted therapies for OA.