Frontiers in Genetics | Applied Genetic Epidemiology

Original Research

Published on 09 Jul 2015

Ancestry of the Timorese: age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world

in Applied Genetic Epidemiology

Margaux A Morrison
Tiago R Magalhaes
Jacqueline Ramke
Silvia E Smith
Sean Ennis
Claire L Simpson
Laura Portas
Federico Murgia
Jeeyun Ahn
Caitlin Dardenne

Frontiers in Genetics

doi 10.3389/fgene.2015.00238

9,451 views
8 citations

General Commentary

Published on 07 Jul 2015

Corrigendum: Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example

in Applied Genetic Epidemiology

Benjamin A Goldstein

Frontiers in Genetics

doi 10.3389/fgene.2015.00231

3,600 views

Mini Review

Published on 30 Jun 2015

Implications of pleiotropy: challenges and opportunities for mining Big Data in biomedicine

in Applied Genetic Epidemiology

Can Yang
Cong Li
Qian Wang
Dongjun Chung
Hongyu Zhao

Frontiers in Genetics

doi 10.3389/fgene.2015.00229

11,329 views
46 citations

Review

Published on 20 Apr 2015

A review of study designs and statistical methods for genomic epidemiology studies using next generation sequencing

in Applied Genetic Epidemiology

Qian Wang
Qiongshi Lu
Hongyu Zhao

Frontiers in Genetics

doi 10.3389/fgene.2015.00149

27,704 views
55 citations

Original Research

Published on 26 Mar 2015

Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease

in Applied Genetic Epidemiology

Jingwen Yan
Sungeun Kim
Kwangsik Nho
Rui Chen
Shannon L. Risacher
Jason H. Moore
Andrew J. Saykin
Li Shen
for the Alzheimer's Disease Neuroimaging Initiative

Frontiers in Genetics

doi 10.3389/fgene.2015.00117

7,424 views
27 citations

Editorial

Published on 17 Mar 2015

The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research

in Applied Genetic Epidemiology

Marylyn D. Ritchie
Mariza de Andrade
Helena Kuivaniemi

Frontiers in Genetics

doi 10.3389/fgene.2015.00104

9,204 views
27 citations

Editorial

Published on 06 Feb 2015

Novel approaches to the analysis of family data in genetic epidemiology

in Applied Genetic Epidemiology

Nathan Morris
Robert C. Elston
Jill S. Barnholtz-Sloan
Xiangqing Sun

Frontiers in Genetics

doi 10.3389/fgene.2015.00027

5,754 views
6 citations

Original Research

Published on 30 Jan 2015

Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project

in Applied Genetic Epidemiology

Sandra L. Laston
V. Saroja Voruganti
Karin Haack
Vallabh O. Shah
Arlene Bobelu
Jeanette Bobelu
Donica Ghahate
Antonia M. Harford
Susan S. Paine
Francesca Tentori

Frontiers in Genetics

doi 10.3389/fgene.2015.00006

9,807 views
17 citations

Original Research

Published on 13 Jan 2015

A statistical framework for testing the causal effects of fetal drive

in Applied Genetic Epidemiology

Nianjun Liu
Edward Archer
Vinodh Srinivasasainagendra
David B. Allison

Frontiers in Genetics

doi 10.3389/fgene.2014.00464

6,696 views
16 citations

Original Research

Published on 11 Dec 2014

Imputation and quality control steps for combining multiple genome-wide datasets

in Applied Genetic Epidemiology

Shefali S. Verma
Mariza de Andrade
Gerard Tromp
Helena Kuivaniemi
Elizabeth Pugh
Bahram Namjou-Khales
Shubhabrata Mukherjee
Gail P. Jarvik
Leah C. Kottyan
Amber Burt

Frontiers in Genetics

doi 10.3389/fgene.2014.00370

42,551 views
131 citations

Original Research

Published on 18 Nov 2014

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts

in Applied Genetic Epidemiology

Bahram Namjou
Keith Marsolo
Robert Carroll
Joshua Denny
Marylyn D Ritchie
shefali setia
Todd Lingren
Aleksey Porollo
Beth cobb
Cassandra Perry

Frontiers in Genetics

doi 10.3389/fgene.2014.00401

14,945 views
80 citations

Original Research

Published on 04 Nov 2014

Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records

in Applied Genetic Epidemiology

David R. Crosslin
Gerard Tromp
Amber Burt
Daniel S. Kim
Shefali S. Verma
Anastasia M. Lucas
Yuki Bradford
Dana C. Crawford
Sebastian M. Armasu
John A. Heit

Frontiers in Genetics

doi 10.3389/fgene.2014.00352

9,157 views
17 citations

General Commentary

Published on 09 Oct 2014

Corrigendum: Analysis pipeline for the epistasis search – statistical versus biological filtering

in Applied Genetic Epidemiology

Shubhabrata Mukherjee

Frontiers in Genetics

doi 10.3389/fgene.2014.00350

4,929 views

Original Research

Published on 05 Aug 2014

Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip

in Applied Genetic Epidemiology

Ankita Parihar
G. Craig Wood
Xin Chu
Qunjan Jin
George Argyropoulos
Christopher D. Still
Alan R. Shuldiner
Braxton D. Mitchell
Glenn S. Gerhard

Frontiers in Genetics

doi 10.3389/fgene.2014.00222

6,788 views
7 citations

Original Research

Published on 05 Aug 2014

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

in Applied Genetic Epidemiology

Robert M. Cronin
Julie R. Field
Yuki Bradford
Christian M. Shaffer
Robert J. Carroll
Jonathan D. Mosley
Lisa Bastarache
Todd L. Edwards
Scott J. Hebbring
Simon Lin

Frontiers in Genetics

doi 10.3389/fgene.2014.00250

14,390 views
70 citations

Methods

Published on 01 Aug 2014

Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example

in Applied Genetic Epidemiology

Benjamin A. Goldstein
Joshua W. Knowles
Elias Salfati
John P. A. Ioannidis
Themistocles L. Assimes

Frontiers in Genetics

doi 10.3389/fgene.2014.00254

12,218 views
52 citations

Methods

Published on 01 Jul 2014

An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies

in Applied Genetic Epidemiology

Sharon M. Lutz
John E. Hokanson
Christoph Lange

Frontiers in Genetics

doi 10.3389/fgene.2014.00188

4,975 views
11 citations

Original Research

Published on 25 Jun 2014

The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study

in Applied Genetic Epidemiology

Iftikhar J. Kullo
Khader Shameer
Hayan Jouni
Timothy G. Lesnick
Jyotishman Pathak
Christopher G. Chute
Mariza de Andrade

Frontiers in Genetics

doi 10.3389/fgene.2014.00166

8,657 views
46 citations

Review

Published on 17 Jun 2014

eMERGEing progress in genomics—the first seven years

in Applied Genetic Epidemiology

Dana C. Crawford
David R. Crosslin
Gerard Tromp
Iftikhar J. Kullo
Helena Kuivaniemi
M. Geoffrey Hayes
Joshua C. Denny
William S. Bush
Jonathan L. Haines
Dan M. Roden

Frontiers in Genetics

doi 10.3389/fgene.2014.00184

11,322 views
75 citations

Review

Published on 02 Jun 2014

Genetic-based prediction of disease traits: prediction is very difficult, especially about the future†

in Applied Genetic Epidemiology

Steven J. Schrodi
Shubhabrata Mukherjee
Ying Shan
Gerard Tromp
John J. Sninsky
Amy P. Callear
Tonia C. Carter
Zhan Ye
Jonathan L. Haines
Murray H. Brilliant

Frontiers in Genetics

doi 10.3389/fgene.2014.00162

36,199 views
67 citations

Original Research

Published on 12 May 2014

Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes

in Applied Genetic Epidemiology

Berta Almoguera
Lyam Vazquez
John J. Connolly
Jonathan Bradfield
Patrick Sleiman
Brendan Keating
Hakon Hakonarson

Frontiers in Genetics

doi 10.3389/fgene.2014.00096

7,457 views
20 citations

Original Research

Published on 09 May 2014

Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections

in Applied Genetic Epidemiology

Zhan Ye
Daniel A. Vasco
Tonia C. Carter
Murray H. Brilliant
Steven J. Schrodi
Sanjay K. Shukla

Frontiers in Genetics

doi 10.3389/fgene.2014.00125

12,185 views
43 citations

Mini Review

Published on 30 Apr 2014

Analysis pipeline for the epistasis search – statistical versus biological filtering

in Applied Genetic Epidemiology

Xiangqing Sun
Qing Lu
Shubhabrata Mukherjee
Paul K. Crane
Robert Elston
Marylyn D. Ritchie

Frontiers in Genetics

doi 10.3389/fgene.2014.00106

9,837 views
66 citations

Methods

Published on 29 Apr 2014

Using previously genotyped controls in genome-wide association studies (GWAS): application to the Stroke Genetics Network (SiGN)

in Applied Genetic Epidemiology

Braxton D Mitchell
Myriam Fornage
Patrick F. McArdle
Yu-Ching Cheng
Sara Pulit
Quenna Wong
Tushar Dave
Stephen R Williams
Roderick Corriveau
Katrina Gwinn

Frontiers in Genetics

doi 10.3389/fgene.2014.00095

11,492 views
35 citations

453 articles

articles

Ancestry of the Timorese: age-related macular degeneration associated genotype and allele sharing among human populations from throughout the world

Corrigendum: Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example

Implications of pleiotropy: challenges and opportunities for mining Big Data in biomedicine

A review of study designs and statistical methods for genomic epidemiology studies using next generation sequencing

Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease

The foundation of precision medicine: integration of electronic health records with genomics through basic, clinical, and translational research

Novel approaches to the analysis of family data in genetic epidemiology

Genetics of kidney disease and related cardiometabolic phenotypes in Zuni Indians: the Zuni Kidney Project

A statistical framework for testing the causal effects of fetal drive

Imputation and quality control steps for combining multiple genome-wide datasets

Phenome-wide association study (PheWAS) in EMR-linked pediatric cohorts

Controlling for population structure and genotyping platform bias in the eMERGE multi-institutional biobank linked to electronic health records

Corrigendum: Analysis pipeline for the epistasis search – statistical versus biological filtering

Extension of GWAS results for lipid-related phenotypes to extreme obesity using electronic health record (EHR) data and the Metabochip

Phenome-wide association studies demonstrating pleiotropy of genetic variants within FTO with and without adjustment for body mass index

Simple, standardized incorporation of genetic risk into non-genetic risk prediction tools for complex traits: coronary heart disease as an example

An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies

The ATXN2-SH2B3 locus is associated with peripheral arterial disease: an electronic medical record-based genome-wide association study

eMERGEing progress in genomics—the first seven years

Genetic-based prediction of disease traits: prediction is very difficult, especially about the future†

Imputation of TPMT defective alleles for the identification of patients with high-risk phenotypes

Genome wide association study of SNP-, gene-, and pathway-based approaches to identify genes influencing susceptibility to Staphylococcus aureus infections

Analysis pipeline for the epistasis search – statistical versus biological filtering

Using previously genotyped controls in genome-wide association studies (GWAS): application to the Stroke Genetics Network (SiGN)