Frontiers in Genetics | Pharmacogenetics and Pharmacogenomics

Original Research

Published on 17 Jan 2013

High-resolution melting analysis of the common c.1905+1G>A mutation causing dihydropyrimidine dehydrogenase deficiency and lethal 5-fluorouracil toxicity

in Pharmacogenetics and Pharmacogenomics

Emma Borràs
Emma Dotor
Àngels Arcusa
Maria José Gamundi
Imma Hernan
Miguel de Sousa Dias
Begoña Mañé
José A G Agúndez
Miguel Blanca
Miguel Carballo

Frontiers in Genetics

doi 10.3389/fgene.2012.00312

8,357 views
12 citations

Review

Published on 07 Jan 2013

Multilocus Genotypes of Relevance for Drug Metabolizing Enzymes and Therapy with Thiopurines in Patients with Acute Lymphoblastic Leukemia

in Pharmacogenetics and Pharmacogenomics

Gabriele Stocco
Raffaella Franca
Federico Verzegnassi
Margherita Londero
Marco Rabusin
Giuliana Decorti

Frontiers in Genetics

doi 10.3389/fgene.2012.00309

5,646 views
15 citations

Review

Published on 02 Jan 2013

Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion

in Pharmacogenetics and Pharmacogenomics

Toshihisa Ishikawa
Yu Toyoda
Koh-ichiro Yoshiura
Norio Niikawa

Frontiers in Genetics

doi 10.3389/fgene.2012.00306

54,854 views
37 citations

Original Research

Published on 03 Dec 2012

Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk

in Pharmacogenetics and Pharmacogenomics

José M Ladero
José A G Agúndez
Carmen Martínez
Gemma Amo
Pedro Ayuso
Elena García-Martín

Frontiers in Genetics

doi 10.3389/fgene.2012.00278

5,029 views
11 citations

Review

Published on 28 Nov 2012

Polymorphisms of Phase I and Phase II Enzymes and Breast Cancer Risk

in Pharmacogenetics and Pharmacogenomics

Christina Justenhoven

Frontiers in Genetics

doi 10.3389/fgene.2012.00258

8,986 views
14 citations

Perspective

Published on 26 Nov 2012

Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain

in Pharmacogenetics and Pharmacogenomics

José A G Agúndez
Francisco Abad-Santos
Ana Aldea
Hortensia Alonso
María Luisa Bernal
Alberto Borobia
Emma Borras
Miguel Carballo
Alfonso Carvajal
José D García-Muñiz

Frontiers in Genetics

doi 10.3389/fgene.2012.00273

9,445 views
24 citations

Review

Published on 22 Nov 2012

Impact of genetic polymorphisms on chemotherapy toxicity in childhood acute lymphoblastic leukemia

in Pharmacogenetics and Pharmacogenomics

Guillermo Gervasini
Jose Manuel Vagace

Frontiers in Genetics

doi 10.3389/fgene.2012.00249

17,082 views
36 citations

Original Research

Published on 21 Nov 2012

Impact of the Interaction between 3′-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes

in Pharmacogenetics and Pharmacogenomics

Rongrong Wei
Fan Yang
Thomas J. Urban
Lang Li
Naga Chalasani
David A Flockhart
Wanqing Liu

Frontiers in Genetics

doi 10.3389/fgene.2012.00248

8,870 views
35 citations

Opinion

Published on 16 Nov 2012

Genetic variations in drug-induced liver injury (DILI): resolving the puzzle

in Pharmacogenetics and Pharmacogenomics

Camilla Stephens
M Isabel Lucena
Raúl J Andrade

Frontiers in Genetics

doi 10.3389/fgene.2012.00253

5,214 views
13 citations

Review

Published on 12 Nov 2012

MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?

in Pharmacogenetics and Pharmacogenomics

Rafael De La Torre
Samanta Yubero-Lahoz
Ricardo Pardo-Lozano
Magi Farre

Frontiers in Genetics

doi 10.3389/fgene.2012.00235

71,962 views
91 citations

Original Research

Published on 05 Nov 2012

ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients

in Pharmacogenetics and Pharmacogenomics

Marelize Swart
Yuan Ren
Peter Smith
Collet Dandara

Frontiers in Genetics

doi 10.3389/fgene.2012.00236

7,342 views
52 citations

Original Research

Published on 02 Nov 2012

Frequencies of 23 Functionally Significant Variant Alleles Related with Metabolism of Antineoplastic Drugs in the Chilean Population: Comparison with Caucasian and Asian Populations

in Pharmacogenetics and Pharmacogenomics

Angela Margarita Roco
Luis Abel Quiñones
José A G Agúndez
Elena García-Martín
Valentina Squicciarini
Carla Estefania Miranda
Joselyn Garay
Nancy Farfán
Iván Nicolás Saavedra
Dante Daniel Caceres

Frontiers in Genetics

doi 10.3389/fgene.2012.00229

11,346 views
69 citations

Review

Published on 10 Oct 2012

Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19

in Pharmacogenetics and Pharmacogenomics

Nuala Ann Helsby
Kathryn Elisa Burns

Frontiers in Genetics

doi 10.3389/fgene.2012.00206

10,291 views
32 citations

Review

Published on 06 Sep 2012

Translesion DNA Polymerases and Cancer

in Pharmacogenetics and Pharmacogenomics

Nick Makridakis
Juergen Reichardt

Frontiers in Genetics

doi 10.3389/fgene.2012.00174

24,971 views
61 citations

Mini Review

Published on 14 Aug 2012

Liver expression quantitative trait loci: a foundation for pharmacogenomic research

in Pharmacogenetics and Pharmacogenomics

Dylan Glubb
Neepa Dholakia
Federico Innocenti

Frontiers in Genetics

doi 10.3389/fgene.2012.00153

7,798 views
13 citations

Original Research

Published on 08 Aug 2012

Submitted for Your Consideration: Potential Advantages of a Novel Clinical Trial Design and Initial Patient Reaction

in Pharmacogenetics and Pharmacogenomics

Matthew Shane Loop
Alexis C. Frazier-Wood
Amy S. Thomas
Emily J. Dhurandhar
James M. Shikany
Gary L. Gadbury
David B Allison

Frontiers in Genetics

doi 10.3389/fgene.2012.00145

5,254 views
5 citations

Original Research

Published on 01 Sep 2011

Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)

in Pharmacogenetics and Pharmacogenomics

Hemant K Tiwari
Amit Patki
Jeffrey Lieberman
T. Scott Stroup
David B Allison
Rudolph L Leibel
Wendy K Chung

Frontiers in Genetics

doi 10.3389/fgene.2011.00056

7,137 views
20 citations

185 articles

articles

High-resolution melting analysis of the common c.1905+1G>A mutation causing dihydropyrimidine dehydrogenase deficiency and lethal 5-fluorouracil toxicity

Multilocus Genotypes of Relevance for Drug Metabolizing Enzymes and Therapy with Thiopurines in Patients with Acute Lymphoblastic Leukemia

Pharmacogenetics of human ABC transporter ABCC11: new insights into apocrine gland growth and metabolite secretion

Analysis of the Functional Polymorphism in the Cytochrome P450 CYP2C8 Gene rs11572080 with Regard to Colorectal Cancer Risk

Polymorphisms of Phase I and Phase II Enzymes and Breast Cancer Risk

Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain

Impact of genetic polymorphisms on chemotherapy toxicity in childhood acute lymphoblastic leukemia

Impact of the Interaction between 3′-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes

Genetic variations in drug-induced liver injury (DILI): resolving the puzzle

MDMA, methamphetamine, and CYP2D6 pharmacogenetics: what is clinically relevant?

ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients

Frequencies of 23 Functionally Significant Variant Alleles Related with Metabolism of Antineoplastic Drugs in the Chilean Population: Comparison with Caucasian and Asian Populations

Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19

Translesion DNA Polymerases and Cancer

Liver expression quantitative trait loci: a foundation for pharmacogenomic research

Submitted for Your Consideration: Potential Advantages of a Novel Clinical Trial Design and Initial Patient Reaction

Association of Allelic Variation in Genes Mediating Aspects of Energy Homeostasis with Weight Gain during Administration of Antipsychotic Drugs (CATIE Study)