Frontiers in Genetics | Predictive Toxicology and Exposomics

Original Research

Published on 23 Oct 2025

Non-polar components in PM2.5 increase matrix remodeling of CRS by up-regulating CEMIP in nasal fibroblasts

in Predictive Toxicology and Exposomics

Jiayao Zhou
Ying Zhu
Huilin Hu
Ru Tang
Shiyao Zhang
Yuelong Gu
Song Mao
Shilei Pu
Hai Lin
Yue Zhao

Frontiers in Genetics

doi 10.3389/fgene.2025.1672729

1,556 views

Editorial

Published on 23 Apr 2025

Editorial: Impact of heavy metal on aquatic life and human health

in Predictive Toxicology and Exposomics

Ahmed H. El-Sappah
Heba H. Abdel-Kader
Manzar Abbas
Sara Zafar
Jia Li

Frontiers in Genetics

doi 10.3389/fgene.2025.1608524

2,603 views
1 citation

Original Research

Published on 04 Apr 2025

Checkpoint and recombination pathways independently suppress rates of spontaneous homology-directed chromosomal translocations in budding yeast

in Predictive Toxicology and Exposomics

Li Zeng
Mingzeng Sun
Michael Fasullo

Frontiers in Genetics

doi 10.3389/fgene.2025.1479307

2,954 views

Original Research

Published on 28 Mar 2025

Differentially expressed and alternately spliced genes as a novel tool for genotoxicity: a computerized study in ATT-myc transgenic mice for the recognition of genotoxic and non-genotoxic chemical

in Predictive Toxicology and Exposomics

Mansour A. Alghamdi
Eman M. El Nashar
Mahmoud Elalfy
Norah S. Al-Zahrani
Mohammed A. Alshehri
Mohammad El-Nablaway
Khulood M. Al-Khater
Rashid A. Aldahhan
Eman G. El-Hadidy
Fathy Sleem

Frontiers in Genetics

doi 10.3389/fgene.2025.1505379

2,925 views

Original Research

Published on 25 Mar 2025

Blood toxicogenomics reveals potential biomarkers for management of idiosyncratic drug-induced liver injury

in Predictive Toxicology and Exposomics

Rachel J. Church
Benedict Anchang
Brian D. Bennett
Pierre R. Bushel
Paul B. Watkins

Frontiers in Genetics

doi 10.3389/fgene.2025.1524433

4,131 views

Original Research

Published on 07 Mar 2025

Tetrahymena thermophila glutathione-S-transferase superfamily: an eco-paralogs gene network differentially responding to various environmental abiotic stressors and an update on this gene family in ciliates

in Predictive Toxicology and Exposomics

Ruth Ortega
Ana Martin-González
Juan-Carlos Gutiérrez

Frontiers in Genetics

doi 10.3389/fgene.2025.1538168

2,138 views

Correction

Published on 17 Feb 2025

Corrigendum: Zearalenone exposure enhanced the expression of tumorigenesis genes in donkey granulosa cells via the PTEN/PI3K/AKT signaling pathway

in Predictive Toxicology and Exposomics

Guo-Liang Zhang
Jun-Lin Song
Chuan-Liang Ji
Yu-Long Feng
Jie Yu
Charles M. Nyachoti
Gong-She Yang

Frontiers in Genetics

doi 10.3389/fgene.2025.1564143

1,208 views

Original Research

Published on 02 Dec 2024

SOLA: dissecting dose-response patterns in multi-omics data using a semi-supervised workflow

in Predictive Toxicology and Exposomics

Wanxin Lai
You Song
Knut Erik Tollefsen
Torgeir R. Hvidsten

Frontiers in Genetics

doi 10.3389/fgene.2024.1508521

2,030 views

Original Research

Published on 22 May 2024

Integrating gene expression and splicing dynamics across dose-response oxidative modulators

in Predictive Toxicology and Exposomics

A. Rasim Barutcu
Michael B. Black
Raymond Samuel
Scott Slattery
Patrick D. McMullen
Andy Nong

Frontiers in Genetics

doi 10.3389/fgene.2024.1389095

2,818 views

Original Research

Published on 17 May 2024

Characteristics of phosgene aspiration lung injury analyzed based on transcriptomics and proteomics

in Predictive Toxicology and Exposomics

Li-Na Wang
Yi-Ru Shao
Peng-Fei Wang
Jiang Lv
Dai-Kun He

Frontiers in Genetics

doi 10.3389/fgene.2024.1393665

2,825 views

Original Research

Published on 09 May 2024

Transcriptomic point of departure determination: a comparison of distribution-based and gene set-based approaches

in Predictive Toxicology and Exposomics

Eduardo Costa
Kamin J. Johnson
Carl A. Walker
Jason M. O’Brien

Frontiers in Genetics

doi 10.3389/fgene.2024.1374791

5,005 views
7 citations

Brief Research Report

Published on 12 Jan 2024

Mft1, identified from a genome-wide screen of the yeast haploid mutants, mediates cell cycle arrest to counteract quinoxaline-induced toxicity

in Predictive Toxicology and Exposomics

Abdallah Alhaj Sulaiman
Dana E. Al-Ansari
Reem Ali
Mustapha Aouida
Dindial Ramotar

Frontiers in Genetics

doi 10.3389/fgene.2023.1296383

3,207 views

Review

Published on 20 Apr 2023

Thallium-induced DNA damage, genetic, and epigenetic alterations

in Predictive Toxicology and Exposomics

Laura Sánchez-Chapul
Abel Santamaría
Michael Aschner
Tao Ke
Alexey A. Tinkov
Isaac Túnez
Laura Osorio-Rico
Sonia Galván-Arzate
Edgar Rangel-López

Frontiers in Genetics

doi 10.3389/fgene.2023.1168713

9,062 views
40 citations

Original Research

Published on 03 Mar 2023

Hepatic gene expression profiles during fed–fasted–refed state in mice

in Predictive Toxicology and Exposomics

Nana Ji
Liping Xiang
Bing Zhou
Yan Lu
Min Zhang

Frontiers in Genetics

doi 10.3389/fgene.2023.1145769

5,428 views
6 citations

Original Research

Published on 15 Feb 2023

Blood transcriptome responses to PFOA and GenX treatment in the marsupial biomedical model Monodelphis domestica

in Predictive Toxicology and Exposomics

Wenqi Cao
Katharine Horzmann
Bettina Schemera
Myra Petrofski
Trisha Kendall
Jennifer Spooner
Patricia E. Rynders
John L. VandeBerg
Xu Wang

Frontiers in Genetics

doi 10.3389/fgene.2023.1073461

4,779 views
2 citations

Original Research

Published on 17 Jan 2023

Preclinical species gene expression database: Development and meta-analysis

in Predictive Toxicology and Exposomics

Caitlin Krause
Kinga Suwada
Eric A. G. Blomme
Kenneth Kowalkowski
Michael J. Liguori
Prathap Kumar Mahalingaiah
Scott Mittelstadt
Richard Peterson
Lauren Rendino
Andy Vo

Frontiers in Genetics

doi 10.3389/fgene.2022.1078050

11,895 views
13 citations