Abstract
The expansion of human and non-human primate central nervous system structures has been a paramount question for classic and contemporary studies in comparative vertebrate neuroanatomy. These studies can benefit from framing data analysis within the Prosomeric Model, which defines a common Bauplan for all vertebrate species, including mammals. According to this model, the vertebrate nervous system is composed of several Fundamental Morphological Units (FMUs) that are defined and delineated by characteristic gene expression profiles. Thus, the expansion of neural structures can be traced back to heterochronic neurogenesis, cell lineage specification, and axon growth in their corresponding FMUs. In the present article, we exemplify the use of the Prosomeric Model as the proper theoretical framework for analyzing the expansion of the cerebral and cerebellar cortices, the pontine nuclei, the striatum, the nigrostriatal dopaminergic system, the thalamus, and the amygdala in primates compared to rodents. We describe the quantitative (volume and neuron number) and qualitative (cytoarchitectonic and cell type differences) expansion of these structures in primates versus rodents and define different expansion modes. Then, we relate these modes to the developmental primary events of specification and secondary events of histogenesis, like neurogenesis. We conclude that the systematic analysis of the molecular regulation of primary and secondary developmental events in each FMU in rats, primates, and other mammals could provide the necessary insight to identify the causal mechanisms of the expansion modes described in the present article.
1 Introduction
Since the dawn of modern studies on brain structure, comparative neuroanatomists have devoted large efforts to identify similarities and differences in the size, cytoarchitecture, chemical composition, synaptic connections, and cell types across the central nervous system in different vertebrate species [e. g.,]. The preservation of “older” and the appearance and expansion of “newer” vertebrate nervous system parts have been explored, quantified, and conceptualized in different scaling models [e. g., ; Yopak et al. (2010)]. These comparative studies are a central core of contemporary neuroscience and have implications that go beyond their own scope; for instance, they can provide sound criteria for defining homology of brain regions in different species, which is key for extrapolating experimental data obtained in laboratory animals to the human brain.
Most of the classic comparative studies of the vertebrate central nervous system were performed within the theoretical framework of the Columnar Model of Charles Judson ; ; and Hartwig , a model that has been proved incompatible with the spatiotemporal expression profiles of morphogenetic genes across vertebrate embryos (Puelles and Rubenstein, 2015). On the contrary, molecular developmental data have provided sound foundations for the Prosomeric Model of Luis Puelles and his coworkers. This model defines a vertebrate nervous system Bauplan (or blueprint) composed of several Fundamental Morphological Units (FMUs), each of them defined and delineated by characteristic gene expression profiles (). More important, the topological neighborhood relationships among FMUs are invariant across vertebrates species (Nieuwenhuys and Puelles, 2016). Thus, Bauplan FMUs seem to have been conserved across all vertebrates and allow for advancing sound homology hypotheses: two brain structures in two different species should be homologous if they are originated in the same FMU of the Bauplan defined by the Prosomeric Model (Puelles and Medina, 2002).
Besides homology criteria, the Prosomeric Model has also proved its efficacy for making predictions on brain connectivity based on the causal mechanisms of development (Puelles, 2022) and explaining malformations (). Thus, this model could provide a fruitful theoretical framework for comparative neuroanatomical studies in search of evolutionary principles. In our opinion, defining principles does not consist only in identifying regularities, like those represented in scaling models. A principle in evolutionary biology also requires a causal mechanism for the identified regularity; and causal mechanisms of nervous system evolution must be searched for in the genetic regulation of embryonic development.
In the present article, we compare the expansion of several central nervous system regions in primates compared to rodents in the light of the Prosomeric Model. Our aim is to exemplify the use of this model for defining different expansion modes of neural structures and propose potential causal mechanisms for such modes. First, we summarize the historical development and major concepts of the Columnar and Prosomeric Models to identify the model that can better explain the differential expansion of primate nervous system parts. Then, we compare the quantitative (volume and neuron number) and qualitative (cytoarchitectonic and cell type differences) expansion of the cerebral and cerebellar cortices, the pontine nuclei, the striatum, the dopaminergic nigrostriatal system, the amygdala, and the thalamus in human and non-human primates compared to rodents. Also, we identify the corresponding FMUs of these structures and compare between rodents and primates the data (when available) on neuron number of each structure. Finally, we define five expansion modes of primate nervous system structures and relate them to the primary events of specification and secondary events of histogenesis in the corresponding FMUs to identify their potential developmental and phylogenetic causal mechanisms.
2 Models of neural tube development and evolution
2.1 The Columnar Model of the vertebrate nervous system
Our current understanding of central nervous system development is rooted in the seminal works of the Swiss embryologist Wilhelm His (1831–1904), who, during the second half of the XIXth century, carried on systematic descriptions of the developing nervous system in human and other vertebrate embryos. His obtained complete series of sections through in toto embedded-in-paraffin embryos, stained the sections with Nissl technique, and used them for 3D reconstructions (Richardson and Keuck, 2022). The illustrations and drawing produced by His are still reproduced in contemporary textbooks of embryology and anatomy [e. g., ].
His described in the neural plate and early neural tube several longitudinal zones, called plates (floor, basal, alar, and roof plates), that extended rostro-caudally along the prospective prosencephalon, mesencephalon, rhombencephalon, and spinal cord [; ; Figure 1A]. He could distinguish the alar and basal plates based on differences in neurogenesis time-course (earlier in the basal than in the alar plate). His model was later rejected in favor of an alternative interpretation that assumed that the notochord, and, thus, the basal plate, did not extend to the anterior end of the neural plate and was present only in the spinal cord, the rhombencephalon, and the mesencephalon [; Figure 1B]. Simultaneously, Charles Judson Herrick (1868–1960) described four longitudinal zones, called columns, abutting on the ventricular surface of the diencephalon. These columns were, from dorsal to ventral, the epithalamus (gives rise to the habenula and the pineal gland), the dorsal thalamus (gives rise to all the thalamic nuclei, except the reticular nucleus), the ventral thalamus (gives rise to the thalamic reticular nucleus, the zona incerta, and the Forel fields), and the hypothalamus. The diencephalic columns showed different neurogenesis time-courses (Reinoso Suárez, 1966) and were outlined by three sulci (dorsal, middle, and ventral diencephalic sulci) that could be identified at different developmental stages [; ; Figure 1C]. The four columns in a devoid of basal plate diencephalon were the touchstone of the Columnar Model (Figure 1D) that was further elaborated by and incorporated to most textbooks of embryology and neuroanatomy [e. g., ; ].
Figure 1
It is important to consider that the Columnar Model is an interpretation of the development of the neural tube and its constituents that is based on observations of vertebrate embryos stained for classic neuroanatomical techniques, like Nissl-staining (Figure 1C). These techniques, in combination with serial sectioning and 3D reconstruction, allow for identifying sulci on the pial and ventricular surfaces of the neural tube (like the diencephalic sulci), bulges on the ventricular surface (like the diencephalic columns), and flexures (like the cephalic and pontine flexures) and dilations (like the diencephalic vesicle) along the neural tube (Figure 1D). In the literature of the Columnar Model [e. g., ], the parts of the developing nervous system delineated by sulci, like the diencephalic columns, are considered fundamental constituents of a vertebrate nervous system Bauplan. Another important tenet of the Columnar Model is the definition of the telencephalon as the most rostral part of the neural tube; thus, the rostro-caudal axis of the neural tube (yellow line in Figure 1D) passes, from rostral to caudal, through the telencephalon, the diencephalon, the mesencephalon, the metencephalon, the myelencephalon, and the spinal cord.
2.2 The Prosomeric Model of the vertebrate nervous system
In parallel to the alar and basal plates, classic developmental studies also described transient transverse structures that were called neuromeres. In the rhombencephalon, several rhombomeres were delineated by obvious sulci between them, but in other neural tube regions the neuromeric organization was less obvious. In spite of this, several neuromeric models were proposed along the XXth century based on classic neuroanatomical techniques [e. g., von Kupffer (1906); Rendahl (1924); ; reviewed in Nieuwenhuys and Puelles (2016) and Puelles (2021)]. Some of this models identified neuromeric boundaries according to differences in neurogenesis time-course (). Importantly, the neuromeric boundaries did not coincide with the sulci between the diencephalic columns, but Kuhlenbeck considered that the initial neuromeric structure was later substituted by the diencephalic columns ().
A new neuromeric model, the Prosomeric Model, was proposed by Luis Puelles (1948–) and his coworkers based on the analysis of in toto chick embryos stained for acetylcholinesterase. This technique stains all the newborn neurons and revealed transverse patterns of neurogenesis that did not coincide with the diencephalic columns (Puelles et al., 1987a). In the last decade of the XXth century, the use of in situ hybridization to color the expression of morphogenetic genes in vertebrate embryos was instrumental to confirm the neuromeric organization of the vertebrate neural tube (Puelles and Rubenstein, 1993; Rubenstein et al., 1994). These studies also showed that Sonic hedgehog (Shh), the morphogenetic determinant of the basal plate, was expressed in the ventral part of the diencephalon (Figure 2A), supporting the presence of a basal plate component in this vesicle as advanced by ; . Puelles and his coworkers also experimentally demonstrated that the most rostral part of the neural tube was the prospective anterior commissure (Puelles et al., 1987b) and defined the Natural axis of the nervous system (yellow line in Figure 2B), which roughly matches the alar-basal plate boundary; also, they have demonstrated that the entire neural tube is epichordal (Puelles and Rubenstein, 2015).
Figure 2
The Prosomeric Model defines the components of the vertebrate central nervous system based on abundant genoarchitectonic data obtained from in situ hybridization experiments performed on vertebrate embryos (Puelles and Ferran, 2012). Genoarchitectonic data has served to identify and delineate several FMUs that constitute the “building bricks” of a common nervous system Bauplan for all vertebrates, including primates. FMUs are patterned during primary events of specification under the induction of several organizers. The notochord and the lateral ectoderm specify the longitudinal floor, basal, alar, and roof plates. The isthmus, the zona limitans intrathalamica (ZLI), and the acroterminal domain (ATD) specify the transverse neuromeres, which are segments of neural tube comprising a representation of the four plates; from caudal to rostral there are twelve rhombomeres (r11-r0; r0 corresponds to the isthmus), two mesomeres (m2-1), and six prosomeres (p1-3, hp1-2, and the ATD). The intersection of longitudinal plates and transverse neuromeres in the neural plate creates a checkboard of histogenetic units, each of them characterized by a specific gene expression profile detected by genoarchitectonic techniques. Further molecular processes within the histogenetic units specify progenitor domains which constitute the FMUs that will give rise to adult brain structures (Figure 2B). The Bauplan formed by the FMUs is conceptualized in the Prosomeric Model [for a review of the Prosomeric Model see Puelles et al. (2013); Nieuwenhuys and Puelles (2016); Nieuwenhuys (2017); ; Puelles (2021)] and takes into account the Natural axis of the central nervous system, which corresponds to the rostro-caudal axis of the early neural tube before it folds [yellow line in Figure 2B: see also Figure 2 in Nieuwenhuys (2017)]. Thus, anatomical descriptors, like rostral, caudal, ventral, and dorsal can be used in a topological sense in relation to this axis; for example, the hypothalamus in the adult brain is topographically ventral to the thalamus but, from the point of view of the Prosomeric Model is topologically rostral to the thalamus. It is important to note that the topological position of each FMU in relation to the others is invariant across vertebrate species. Such invariancy allows to propose homology hypothesis based on Field homology: two nervous system structures in two different vertebrate species are homologues if they originate in the same FMU (Puelles and Medina, 2002).
According to the Prosomeric Model, the hypothalamus is a derivative of the floor, basal, and alar plates of hp1, hp2, and the ATD and the telencephalon is a topologically dorsal extension of the alar plate of prosomere hp1, with a small contribution from hp2 (Puelles and Rubenstein, 2015). Four subpallial and six pallial FMUs are specified in the telencephalon. The subpallial FMUs are Striatum (St, gives rise to the striatum), Pallidum (Pal, gives rise to the globus pallidus and the lateral part of the bed nucleus of the stria terminalis), Diagonal (Dg, gives rise to basal prosencephalic structures and the medial part of the bed nucleus of the stria terminalis), and Preoptic (POA, the only part of the telencephalon originated in the alar plate of hp2; gives rise to the preoptic region) (; Medina et al., 2011). The pallial FMUs are the medial pallium (gives rise to the hippocampal allocortex and the entorhinal cortex), the ventral pallium (gives rise to the primary olfactory cortex and the olfactory bulb), the lateral pallium (gives rise to paraolfactory mesocortices), the mesomedial pallium (a hypothetical pallial sector that should give rise to the parahippocampal mesocortices), the dorsal pallium (gives rise to the isocortex), and the amygdalar pallial sector (Puelles et al., 2019; ). Amygdalar nuclei are originated in the amydalar pallial sector but also in the four subpallial FMUs [; Puelles et al. (2019); Figure 2C]. Several smaller FMUs have been identified within the amygdalar pallial sector ().
The thalamus was considered a diencephalic column in the Columnar Model of ; ; and , but genoarchitectonic data show that it is originated in the alar plate of p2, with the exception of the thalamic reticular nucleus, which is originated in the alar plate of p3. Five smaller FMUs have been identified in the alar plate of p2 [Martinez-Ferre and Martinez (2012); Redies et al. (2000); Figure 2D].
In the rhombencephalon, twelve rhombomeres have been identified based on cytoarchitectonic boundaries and gene expression profiles (Nieuwenhuys, 2011). The rhombic lip is a region of the alar plate adjacent to the floor plate that extends from r0 to r10. This region is specialized in producing neurons that will tangentially migrate long distances, like the inferior olive, the pontine nuclei, and the cerebellum. The inferior olive originates from tangential migrations starting at the rhombic lip from r10 to r8 and ending in the basal plate of these same rhombomeres (Tomas-Roca et al., 2016). The pontine nuclei are originated by massive tangential migrations starting at the rhombic lip from r8 to r6; these migrations transverse several rhombomeric boundaries and invade the basal plate of r3 and r4 (Tomas-Roca et al., 2016; ). The rhombic lip also contributes to form the cerebellum, which has a dual origin. First, excitatory cerebellar neurons are originated in the rhombic lip at r1 and tangentially migrate to populate the prospective cerebellar cortex and the deep cerebellar nuclei. Second, GABAergic inhibitory cerebellar neurons originate in a different sector of the ventricular zone in the alar plate of r1 and radially migrate to the prospective cerebellar cortex and the deep cerebellar nuclei [Martinez et al. (2013); Figure 2E].
2.3 The Columnar and the Prosomeric Models face to face
The Columnar and the Prosomeric Models propose two different Bauplans for the vertebrate nervous system from two different epistemological and ontological frameworks (Table 1). The Columnar Model is based on the microscopic examination and 3D reconstruction of embryos that are cut and stained with classic techniques, like Nissl staining (Figure 1C). These techniques allow for identifying sulci, bulges, and columns produced by differential growth of some parts of the neural tube over others. Finally, the Columnar Model describes an axis of the neural tube that considers the telencephalon as its most rostral part.
Table 1
| Columnar Model | Prosomeric Model | |
|---|---|---|
| Basic references | ; ; ; ; | Puelles et al. (1987a); Puelles and Rubenstein (1993); Nieuwenhuys and Puelles (2016); Nieuwenhuys (2017) |
| Anatomical techniques used | Classical stains | Genoarchitecture |
| Definition of boundaries | Sulci | Gene expression boundaries |
| Axis of the central nervous system | Adult nervous system Central axis | Natural axis (alar-basal plate boundary) |
Epistemological differences between the Columnar and the Prosomeric Models.
In contrast, the Prosomeric Model is based on the microscopic examination of embryos that are stained with in situ hybridization and immunohistochemistry to color the expression of morphogenetic genes, like Shh. These techniques allow for identifying boundaries between parts of the embryo that express a given gene and other parts that do not express it; for instance, Shh is expressed in the basal plate, but not in the alar plate (Figure 2A). Finally, the Prosomeric model uses the Natural axis of the neural tube that roughly matches the alar-basal plate boundary and considers that the entire neural tube is epichordal.
The use of different staining techniques provides each model with different ontological power because the classic stains of the Columnar Model and the genoarchitectonic stains of the Prosomeric Model detect different events of development. In embryos, we can define three types of events [Nieuwenhuys and Puelles (2016); Table 2]. First, the primary events of specification are the result of induction processes directed by organizers like the notochord or the isthmus; there are several levels of specification, from the specification of the neural plate by the hypoblast and the primitive node () to the specification of histogenetic units and FMUs. Second, the secondary events of histogenesis comprise all the cellular processes, like neurogenesis, cell migration, or axon growth, that lead to circuit formation after FMUs are specified. Finally, the tertiary events of morphogenesis consist in the appearance of sulci in the ventricular and pial surfaces of the neural tube, in the deformation of the neural tube like and accordion, and in the enlargement of vesicles, columns, and eminences due to the differential growth of some FMUs over others; the tertiary events of morphogenesis also comprise the formation of grisea (thalamic nuclei, cortical layers, etc.) after secondary events finalize. Thus, the Columnar Model uses tertiary events of morphogenesis (like the diencephalic columns separated by the diencephalic sulci) to define the constituents of the neural tube. In contrast, the Prosomeric Model defines FMUs of the nervous system according to the primary events of specification.
Table 2
| Primary events (Specification) | 1st level Specification of the neural plate |
| 2nd level Specification of floor, alar, basal, and roof plates Specification of neuromeres The intersection of plates and neuromeres produces a checkboard of histogenetic units | |
| 3rd level Specification of FMUs in the histogenetic units | |
| 4th level Further lineage specification in the FMUs | |
| Secondary events (Histogenesis) | Neurogenesis |
| Cell migration | |
| Axon navigation and growth | |
| Dendrite growth | |
| Cytoplasmic differentiation | |
| Cell nucleus differentiation | |
| Synapse formation | |
| Synapse pruning | |
| Myelination | |
| Tertiary events (Morphogenesis) | Sulci |
| Flexures | |
| Vesicles | |
| Eminences | |
| Columns | |
| Formation of nuclei and layers |
Types of events during embryological development.
In comparative and evolutionary neuroanatomy, the choice of one Bauplan model over another is not a trivial question. Specifically, the genetic mechanisms that underlie changes in the relative dimension of nervous system parts [“mosaic” evolution; ] could be searched for in the constituent units of the Columnar or the Prosomeric Model Bauplans. We consider that the Prosomeric Model, with FMUs defined by the primary events of specification, provides a better framework for investigating differential expansion of nervous system parts across species than the Columnar Model. For instance, the expansion of the pontine nuclei in primates should be studied in the rhombic lip of rhombomeres r6-8, two of which are cryptorhombomeres that are identified using genoarchitectonic techniques [Tomas-Roca et al. (2016); Figure 2E]. Regarding the diencephalon, one FMU corresponds to the epithalamus column of Herrick, but other four FMUs have been identified in the alar plate of p2, which corresponds to the dorsal thalamus column [Martinez-Ferre and Martinez (2012); Figure 2D]; each of these thalamic FMUs is differentially expanded in vertebrates [see Figure 5 in Puelles (2001)]. Finally, in the telencephalon the subpallial ganglionic eminences, which are bulges on the ventricular surface due to tertiary events of morphogenesis, are composed of four FMUs, each of them with specific contributions to subpallial nuclei [Puelles et al. (2016); Figure 2C]; on the other hand, the pallium is composed of six FMUs [five of them give rise to the cerebral cortex and one to the pallial amygdala, Puelles et al. (2019); Figure 2C] that are differentially expanded in primates compared to rodents ().
In summary, the Prosomeric Model provides an ontology of central nervous system parts based on the primary events of specification, which are mediated by the action of gene regulatory networks that direct and coordinate the development of the vertebrate nervous system. Also, the Prosomeric Model Bauplan allows to propose homology hypothesis based on Field homology. Therefore, the FMU-based ontology provides a framework for meaningful interspecies comparison and searching for causal mechanisms of nervous system part expansion in phylogeny.
3 Expanded nervous system structures in humans compared to rats
A first look at the rat and human central nervous systems brings to light quantitative differences. Figure 3 shows several adult rat central nervous system regions around a micrograph of a parasagittal section stained with Nissl. Figure 3A represents a fate map of the early pallium from a rat embryo with the six pallial FMUs, Figure 3B represents the cortical gradient of laminar complexity with its different cortical types (allocortex, mesocortex, eulaminate), Figure 3C represents in grayscale these cortical types on the fate map of the early pallium, and Figure 3D shows higher magnifications of representative cortical regions with different grade of laminar complexity. Other regions, like the dorsal (Figure 3E) and ventral striatum (Figure 3F), the thalamus (Figure 3G), and the cerebellar cortex (Figure 3H), are showed in higher magnification.
Figure 3
In contrast, Figure 4 shows schemes of several adult human central nervous system regions on top of and on a parasagittal section drawing [from the Atlas of ]. Figure 4A represents the cortical gradient of laminar complexity with its different cortical types (allocortex, mesocortex, eulaminate I, eulaminate II, eulaminate III, koniocortex), Figure 4B represents in grayscale these cortical types on the fate map of the early pallium, and Figure 4C represents the same cortical types on the surface of the left hemisphere. Other brain regions, like the thalamus, the pons, the inferior olive, and the cerebellum, are highlighted on the parasagittal section drawing (Figure 4D).
Figure 4
The expansion of the cerebral cortex, the pons, and the cerebellum in the human compared to the rat nervous system stands out at first sight when comparing Figures 3 and 4. In the following sections, we will analyze the quantitative (volume and neuron number) and qualitative (cytoarchitectonic and cell type differences) expansion of the cerebral and cerebellar cortices, the pontine nuclei, the striatum, the dopaminergic nigrostriatal system, the amygdala, and the thalamus in human and non-human primates compared to rodents. We will define several expansion modes and trace them back to the developmental primary events of specification and the secondary events of histogenesis, like neurogenesis and axon growth, in their corresponding prosomeric FMU.
3.1 Tangential expansion of the primate cerebral cortex: “quantitative and qualitative expansion”
The primate cerebral cortex is significantly expanded compared to rodents. This expansion is not merely a quantitative extension of cortical surface by the addition of more cortical columns with comparable laminar composition. On the contrary, new cortical types of higher laminar complexity that are absent in the rat cortex appear in the primate (). The appearance of new isocortical types (Eulaminate II, Eulaminate III, and Koniocortex; Figure 4A), was first observed in the human cortex by Friedrich Sanides (1962) and is at the base of the Hypothesis on the Dual Origin of the Neocortex (Sanides, 1970; ). This hypothesis is supported, at least partially, by genoarchitectonic data obtained in mammalian embryos that suggest that the tangential expansion of the human and non-human primate cerebral cortex seems to have been directed by molecular signalling form developmental organizers like the hem, the anti-hem, and the septocommisural roof plate (Puelles et al., 2019). Primate cortical expansion seems to involve the specification of new isocortical (eulaminate) types in the dorsal pallium FMU (Figure 4B), as suggested by .
We have described previously in detail the cytoarchitecture of cortical types along the gradients of laminar complexity in rat, macaque, and human cerebral cortices (; ; ; ; ). We have also described the differences in the embryonic cortical layers of rats and humans, highlighting the absence of intermediate progenitors in the rat cortex and in prospective human mesocortical areas and their abundance in prospective human eulaminate areas (; ). Briefly, the tangentially expanded part of the primate cerebral cortex (eulaminate II, eulaminate III, and koniocortical areas) requires an expanded germinal zone composed of ventricular and well-developed subventricular (including outer subventricular) zones (Reillo et al., 2011); the latter, which is underdeveloped in the rat embryonic cortex and in prospective mesocortical human areas, contains intermediate progenitors that produce the abundant granular neurons in layer IV and the projection neurons in layers II and III. It is important to recall that eulaminate II, eulaminate III, and konicortical areas in the primate cortex have higher neuron density at the expenses of their layers II, III, and IV than mesocortical areas (O'Kusky and Colonnier, 1982; ; ). Also, the expanded primate cerebral cortex contains more GABAergic interneurons than the rodent cortex [25% and 15% of the total neuron population, respectively; ]; in the latter species cortical GABAergic interneurons are originated in subpallial domains and tangentially migrate to the cortical plate (Marin and Muller, 2014), but in primates they are also originated in pallial sectors (; ; ) and probably migrate guided by radial glia, like cortical excitatory neurons do.
In summary, the tangential expansion of the human cerebral cortex (Figure 4A) consisted in the addition of cortical types that do not exist in rodents (Figure 3B). These new types are probably specified in concentric rings within the dorsal pallial FMU (Figure 4B) and contain a well develop subventricular zone with abundant intermediate progenitors. The new cortical types in primates have more excitatory neurons in layers II–IV than in layers V–VI and more GABAergic interneurons across all layers from both pallial and subpallial origin. Thus, we describe the expansion mode of the human cerebral cortex as “Quantitative and qualitative expansion”.
3.2 Primate pontine nuclei, cerebellum, and striatum expansion: “general quantitative expansion”
Several circuits involving the cerebellum and pontine nuclei support different aspects of cortical function [; Figure 5]. Extensive cortical regions project to the pontine nuclei, which in turn project to the contralateral cerebellar cortex. Then, Purkinje neurons in the cerebellar cortex project to the deep cerebellar nuclei, which in turn project to the contralateral thalamus. Thalamocortical neurons in the cerebellar thalamic territory close the loop projecting back to frontal cortical areas (Schmahmann and Pandya, 2008). The development of these circuits involves the specification of cerebral cortex, pontine, cerebellar, and thalamic neurons in the alar plate of neuromeres hp1, r6-8, r1, and p2, respectively (Figures 2C–E). Pontine neurons are originated in the alar plate (rhombic lip) of r6-8. Excitatory cerebellar neurons (granule cells in the cerebellar cortex and neurons in the deep cerebellar nuclei) are originated in the rhombic lip of r1, while GABAergic cerebellar neurons (like Purkinje cells) are originated in another sector of the alar plate in r1 (). The thalamic nuclei that receive the deep cerebellar nuclei projection, like the ventral posterior lateral nucleus–oral part (), are originated in the Dorsal Thalamus dorsal tier (DTd; in the alar plate of p2) FMU (Puelles, 2001). Finally, the frontal areas that receive projections originated in the cerebellar thalamic territory are originated in the mesomedial pallium (mesocortical cingulate motor areas) and the dorsal pallium (isocortical frontal areas) (Puelles et al., 2019; ).
Figure 5
Contrary to the cerebral cortex, there is not significant variation in the neuron types that constitute the cerebellum and the pontine nuclei in primates compared to rodents. Actually, the cerebellar cytoarchitecture and cellular composition does not change significantly in primates compared to rodents (; ), but the human cerebellar cortex has a much higher index of gyrification than the rat cerebellar cortex (compare Figures 3, 4). Regarding the pontine nuclei, it seems that the differences between rodents and primates are quantitative (with a significant expansion of these nuclei in the human brainstem as showed in Figure 4D) without the addition of new neuron types (Mihailoff et al., 1981; Schmahmann and Pandya, 1997). In summary, the expansion of the primate cerebellum and pontine nuclei does not involve major cytoarchitectonic modifications and probably “just” consists in the addition of more neurons of basically the same types as in rodents. Therefore, we describe the expansion mode of these structures as “General quantitative expansion”.
Besides ponto-cerebellar circuits, the basal ganglia also support cortical function. The striatum is the most important input nuclei of the basal ganglia, and its sectors [olfactory tubercule (TOL), nucleus accumbens (NAc), putamen (Put), and caudate (Cd); originated from the St subpallial FMU; reviewed in ] receive projections from the entire cerebral cortex. Synaptic tract-tracing studies in primates show that corticostriatal projections are arranged topographically in parallel to cortical type; thus, hippocampal and olfactory allocortices project to TOL and NAc, mesocortical areas project mostly to NAc, and isocortical eulaminate areas project to Put and Cd (Figures 6A, B). In rats, corticostriatal projections are also arranged in parallel to cortical type (Figures 7A, B), but the cortical gradient of laminar complexity in these species does not include highly eulaminate isocortical types (Figures 3B, 7A). Therefore, the pattern of corticostriatal projections in primates and rats is compatible with a striatal expansion in parallel to the tangential cortical expansion [see ]. Contrary to the cortex, the overall cytoarchitecture and neuron composition of the rat and primate striatum does not vary significantly across striatal nuclei or species, with medium spiny neurons constituting over 80% of the entire neuron population in the striatum of rodents and primates (). We can conclude that the expansion of the striatum in primates, like the cerebellum and the pontine nuclei, follows a “General quantitative expansion”.
Figure 6
Figure 7
3.3 Primate dopaminergic nigrostriatal pathways: “telodendrion expansion”
Besides corticostriatal pathways, the striatum receives dopaminergic projections from the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA). These projections are key for motor and cognitive functions and are disrupted in neuropsychiatric disorders like Parkinson’s disease [reviewed in ]. The macaque striatum volume increases one order of magnitude compared to rodents and the human striatum is nearly 10 times larger than the macaque striatum (Figure 8A). Thus, the striatum volume in humans compared to rodents increases in a logarithmic scale (Figure 8B). In contrast, the number of dopaminergic SNc neurons increases only in one order of magnitude in humans compared to rodents (Figure 8C). Thus, each dopaminergic neuron in the human SNc must provide innervation to four times more striatal volume than equivalent macaque neurons and ten times more striatal volume than equivalent rodent neurons (Figure 8D). It is important to note that the striatal volume occupied by neuropil compared to the volume occupied by neuron bodies also increases in humans compared to rodents. This is evidenced by microscopic examination of the striatum in Nissl-stained sections (Figures 8E–H); Nissl technique stains neuron bodies and the nuclei of neurons, glial, and endothelial cells, but leaves the neuropil (dendrites, spines, axons, axon terminals, and synapses) unstained. Thus, human dopaminergic SNc neurons must innervate not only larger striatal volumes than those innervated by macaques and rodents, but also enriched-in-synapses volumes. We hypothesize that, in order to provide dopaminergic innervation to their corresponding enriched-in-neuropil larger striatal volumes, human dopaminergic SNc neurons may have significantly longer telodendrions (Figure 6B) than those of rodent nigral neurons (Figure 7B). The increase in body size of SNc neurons in primates compared to rodents (Figures 8I–K), especially in humans (Figure 8L), may reflect larger metabolic burdens of human dopaminergic SNc neurons due to their longer telodendrions and higher number of synapses, which, as has been suggested (), may render human SNc neurons vulnerable to Parkinson’s disease. In summary, we describe the expansion mode of the primate dopaminergic nigrostriatal system as “Telodendrion expansion”.
Figure 8
3.4 The primate vs rat amygdala: “focal quantitative expansion”
The amygdala is composed of pallial and subpallial nuclei. Cytoarchitectonic studies in rat, macaque, and human amygdala have identified a comparable set of nuclei, with the only probable exception of the primate paralaminar nucleus, as showed in Figure 9. Some amygdalar nuclei originate in the four subpallial FMUs [; red, Figures 9A–C] and others originate in several FMUs within the pallial amydalar sector [; yellow, Figures 9A–C]. Subpallial amygdalar nuclei are composed mostly of GABAergic neurons and issue inhibitory projections (red pathways, Figure 9C) to effector autonomic nuclei in the hypothalamus and the brainstem. On the other hand, pallial amygdalar nuclei are composed mostly of excitatory neurons (green pathways, Figure 9C) and have reciprocal connections with mesocortical limbic and isocortical multimodal and unimodal associative areas.
Figure 9
The amygdalar volume in macaques (Figure 9C) and humans (Figure 9B) increases compared to rats (Figure 9A). But this volume expansion is not homogeneous, because the relative size of the subpallial and the cortical pallial nuclei is not preserved. Actually, the Lateral (L), Basolateral (BL), and Basomedial (BM) nuclei are significantly expanded in macaques compared to rats and in humans compared to macaques (Figure 9). The expanded primate amygdalar nuclei are connected to mesocortical and isocortical areas (; ; Timbie et al., 2020), suggesting that they expand in parallel to the isocortex. The expansion of pallial amygdalar nuclei does not seem to have involved the appearance of different neuron types, because the amygdala in rodents (Millhouse and DeOlmos, 1983; Millhouse, 1986) and primates (Ulfig et al., 2003; Zikopoulos et al., 2016) is composed of comparable neuron types. Therefore, we describe the expansion mode of the primate amygdala as “Focal quantitative expansion”.
3.5 The primate thalamus: “focal quantitative and cell lineage expansion”
The human thalamus (Figure 4D) is larger than the rat thalamus (Figure 3G), but, contrary to the amygdala, there are also qualitative differences in the cytoarchitectonic parcellation of thalamic nuclei across these species. Comparable functional nuclear groups are identified in the rat and human thalamus according to their synaptic connections (Figures 10A–H), but some of them, like the pulvinar complex and the ventral motor nuclei, are expanded and include further subdivisions in humans that are not identified in rats.
Figure 10
The developmental origin of thalamic nuclei has been traced to four FMUs in the alar plate of p2, with the exception of the thalamic reticular nucleus, which is originated in the alar plate of p3 (Figure 2D). This FMUs are the Epithalamus, the Dorsal Thalamus dorsal tier (DTd), the Dorsal Thalamus intermediate tier (DTi), the Dorsal Thalamus ventral tier (DTv), and the Dorsal Thalamus anteroventral tier (DTav) (Redies et al., 2000; Puelles, 2001; Martinez-Ferre and Martinez, 2012; ). The thalamic nuclei originated in each of these FMUs are represented in Figures 10I–L for the rat thalamus and in Figures 10M–P for the human thalamus. Most nuclei in the rat and human thalamus originate from DTd, which rises the following question: Are smaller FMUs specified within DTd that would give rise to specific sets of thalamic nuclei, like pulvinar or ventral motor nuclei? Further developmental studies may identify smaller thalamic FMUs like those recently described in the pallial amygdala ().
Regarding neuron composition, there is a significant difference between the rat and human thalamus. It has been known since the studies of Ramón y Cajal (1903; 1966) that the human thalamus is enriched in interneurons, which are scarce in the rodent thalamus. These interneurons, like the thalamic reticular neurons, are GABAergic () and in the rat thalamus are mostly restricted to the dorsal lateral geniculate nucleus (Figures 10Q–T); in contrast, in the primate thalamus there are GABAergic interneurons across all nuclei () (Figures 10U–X). Thus, in the primate thalamus there are more GABAergic interneurons than in the rodent thalamus. In addition, thalamic GABAergic interneurons also have an outstanding feature that makes them a “game changer” for primate thalamic circuits. They have dendrites endowed with flat and pleomorphic GABA-containing vesicles that can be the presynaptic element in symmetric (GABAergic) synapses with other dendrites (Peters et al., 1991; Tai et al., 1995). Presynaptic inhibitory dendrites in the primate thalamus contribute to the formation of complex synaptic arrangements (; Timbie et al., 2020) that increase the complexity of thalamic circuits compared to rodents. Therefore, we describe the expansion mode of the primate thalamus as “Focal quantitative and cell lineage expansion”.
4 Potential causal mechanisms of expansion modes in the primate nervous system
In the previous sections we have defined several expansion modes according to differences in the cytoarchitecture and cell type composition of several expanded nervous system regions in primates compared to rodents. In Table 3 we summarize these expanded structures, their corresponding FMU, and the expansion modes features. In the following sections, we discuss the potential developmental causal mechanisms underlying the expansion modes in relation to the primary and secondary developmental events in the corresponding FMUs.
Table 3
| Structure | FMU | Expansion mode | ||
|---|---|---|---|---|
| Mode | Cytoarchitectonic expansion | Cell type expansion | ||
| Cerebral cortex | Alar plate hp1 (MP, MMP, DP, LP, VP; St, Pall, Dg) | Quantitative and qualitative expansion | New cytoarchitectonic cortical types | More excitatory projection neurons and interneurons for layers II–IV More GABAergic interneurons of pallial and subpallial origin |
| Pontine nuclei | Alar plate r6-8 (Rhombic lip) | General quantitative expansion | Same basic cytoarchitecture | Same basic cell types |
| Cerebellar cortex | Alar plate r1 (Rhombic lip and adjacent matrix) | General quantitative expansion | Same basic cytoarchitecture | Same basic cell types |
| Striatum | Alar plate hp1 (St) | General quantitative expansion | Same basic cytoarchitecture | Same basic cell types |
| Nigrostriatal system | Floor and basal plates p1-3, m1-2 | Telodendrion expansion | Same basic cytoarchitecture | Same basic cell types |
| Amygdala | Alar plate hp1 (Pallial amygdala) | Focal quantitative expansion | Same basic cytoarchitecture with expansion of some pallial nuclei | Same basic cell types |
| Thalamus | Alar plate p2 (DTd) | Focal quantitative and cell lineage expansion | New cytoarchitectonic nuclei and expansion of other nuclei | More GABAergic interneurons |
Expansion modes of human nervous system structures.
For abbreviations see Figure 3.
4.1 Neurogenetic heterochrony across species
The different expansion modes of nervous system structures in human and non-human primates compared to rodents described in the previous sections (Table 3) have been quantified volumetrically in several scaling models [e. g., ; Yopak et al. (2010)]. Differences in volume can be due to differences in several cellular factors like the total neuron number, the extension of dendritic arborizations, the length of telodendrions, or the amount of myelin. Of all these cellular factors, which are the result of secondary events of histogenesis (Table 2), the total neuron number is the most comparable across species because it can be unbiasedly quantified using stereological methods (Figure 11). The total encephalic, the total cerebral cortex, and the cerebellum neuron number in humans are nearly one order of magnitude higher than in macaques and two orders of magnitude higher than in rodents (Figures 11A–C; the data summarized in this figure were obtained from studies that used unbiased stereological methods – see figure legend and Supplementary Material File). This raises the question of whether the human brain expansion is “concerted” (isometric expansion of all human brain parts) or “mosaic” [some parts expand more than other; ; ]. In general, it is acknowledged that, in vertebrates, some brain parts expand more than others [e. g., birds have larger optic tectum, which develops in the alar plate of neuromere m1 (Puelles, 2016; Puelles, 2018), than mammals; ] and such differential expansions have been related to differential neurogenesis in the prospective expanded regions compared to the non-expanded [e. g., zebra finches -Passerines- have larger telencephalon and thicker proliferative pallial and subpallial subventricular zone than quails -Galliformes-; ]. A recent study compared neurogenesis in lizard, chicken, and rat embryos and concluded that relative size differences of nervous system parts must result from developmental proliferative heterochrony (). In fact, the vast number of neurons that are generated during human prenatal development implies longer neurogenetic periods, especially in the most expanded regions like the cerebral and cerebellar cortices. The classic article of , who performed a semi quantitative description of the germinal matrix across developing neural structures in human embryos (Figure 12A), showed that alar plate derivatives (like the cerebral cortex, the striatum, the thalamus, or the spinal cord posterior horn) start and finalize their neurogenetic period later than basal plate derivatives (like the spinal cord anterior horn) resulting in longer neurogenetic periods. Actually, some of the alar plate derivatives have extended periods of neurogenesis in human embryos: in the cerebral cortex and the striatum neurogenesis ends by gestational week 26 (; ) and in the cerebellum there is neurogenesis until the first years of postnatal life (Ten Donkelaar and Lammens, 2009; ); in contrast, other alar plate derivatives, like the thalamus, finalized their neurogenesis by gestational week 10.
Figure 11
Figure 12
The study of Kahle suggest that embryonic plates have intrinsic different neurogenetic capacity. All the expanded human nervous system structures analyzed in the present article are alar plate derivatives, except the SNc. Why the logarithmic volumetric increase of the primate striatum along phylogeny has not been paralleled by logarithmic increase in the number of dopaminergic SNc neurons? The answer may be in the developmental constrains of the FMUs that give rise to the SNc, which is a plurisegmental nucleus whose neurons are originated in the paramedian subdomain of the floor plate and in the adjacent medial sector of the basal plate along neuromeres p1-3 and m1-2; later, SNc neurons tangentially migrate to the superficial stratum of the basal plate in the neuromere where they were originated (Puelles and Verney, 1998; Verney et al., 2001; ). Importantly, the neurogenetic period that gives rise to the SNc in macaques lasts from embryonic day 36 (E36) to E43 (), a much shorter neurogenesis period compared to macaque alar plate derivatives like the thalamus [from E25 to E50; Spadory et al. (2022)], the striatum [from E36 to E80; ; ], the mesocortex [from E40 to E70; ], and the koniocortex [from E45 to E102; Rakic (1974)]. This points to a severe constrain in the neurogenetic capacity of the floor and basal plates, whose shorter periods of neurogenesis and earlier maturation compared to the alar plate () were already observed by Wilhelm ; .
In summary, some FMUs, like those in the floor and basal plates, have developmental constrains that impede their phylogenetic expansion. In contrast, alar FMUs seem to have higher phylogenetic flexibility and differentially expand across vertebrates (e. g., the optic tectum in birds, the cerebral cortex in mammals, the pontine nuclei in primates). These different developmental constrains would explain “mosaic” expansion of some nervous system parts over others.
4.2 Genetic regulation of primary and secondary developmental events
Some studies have addressed neurogenetic heterochrony in different vertebrate species [e. g., ; Striedter and Charvet (2008); ; ] and related those differences with genetic regulation of primary events of specification and secondary events of histogenesis [summarized in and Montgomery et al. (2016)]. Several mechanisms have been described to account for nervous system “mosaic” expansion. First, the gene expression boundaries (primary events of specification) can vary in different species (Menuet et al., 2007; Sylvester et al., 2010) and, thus, modify the FMU limits resulting in larger or smaller progenitor populations. Second, the neurogenetic period in a given FMU can last longer in different species (Striedter and Charvet, 2009; ). Finally, cell rate-division can be shorter (). Of these three developmental mechanisms for “mosaic” expansion the first one (primary event modification) is probably the less frequent because the Prosomeric Bauplan and its gene regulatory networks (Figures 12B–D) seem to be strongly conserved across vertebrates. The other two mechanisms can explain larger production of neurons, which would account for some of the expansion modes described in the present article. Thus, most, but not all, differences in nervous system structure across vertebrates must be due to the time-course and magnitude of secondary events of histogenesis in already specified FMUs.
The tangential expansion of the primate cerebral cortex shows the most complex expansion mode (“Quantitative and qualitative”) described in the present article. The primate cerebral cortex is larger, has new cytoarchitectonic cortical types, more excitatory neurons, and more GABAergic interneurons compared to the rodent cerebral cortex. This expansion may imply changes in the primary events of specification in the early primate pallium that may specify novel FMUs (compare Figure 3C with Figure 4B) with more intermediate progenitors in the outer subventricular zone, as suggested by . Also, the expanded primate cortex has significantly increased neurogenesis probably by longer neurogenetic periods in the pallial FMUs, whose neuroblasts radially migrate to the cortical plate. Finally, more GABAergic interneurons are produced both in pallial and subpallial FMUs; those produced in the latter tangentially migrate to their cortical destination. Importantly, primate cortical GABAergic interneurons do have different morphology [as already noted by Ramón y Cajal et al. (1988)] and are classified in different biochemical subclasses () than rodent cortical GABAergic interneurons [reviewed in ], which may imply the specification of new cell lineages. Altogether, the “Quantitative and qualitative” expansion mode of the primate cerebral cortex may be due to variations in the primary events of specification in the pallium together with variations in the secondary events of histogenesis of pallial and subpallial FMUs.
In contrast to the cerebral cortex, other primate alar pate derivatives, like the cerebellar cortex, the pontine nuclei, and the striatum, show “General quantitative expansion” without significant cytoarchitectonic modification or new cell types compared to rodents. Contrary to the cerebral cortex, the expansion modes of these other alar plate derivatives may not involve the specification of novel FMUs and are probably due to variations in the secondary events of histogenesis, like neurogenesis, in the corresponding FMUs. These differences in secondary events should be regulated by the morphogenetic genes that specify the FMUs (Figures 12C, D). For instance, the transcription factor Gbx2 is expressed in prospective cerebellar granule cell neurons () and restricts the expression of her5, a repressor of neurogenesis (Nakayama et al., 2017). Thus, different modulation of Gbx2 in the primate cerebellum compared to other species could direct the expansion of the granule cell progenitor pool.
The primate amygdala shows “Focal quantitative expansion” in some pallial nuclei, without the addition of new cytoarchitectonic nuclei, with the only probable exception of the paralaminar nucleus (Figure 9). The most expanded nuclei are originated in several small FMUs identified in the pallial amygdalar sector; interestingly, these small FMUs also give rise to pallial nuclei that do not significantly expand, like the cortical amygdalar nuclei (). The primate thalamus shows “Focal quantitative expansion” in some nuclei, but, contrary to the amygdala, it also shows the appearance of new nuclei (like some ventral and the pulvinar nuclei) that are not identified in rodents; further genoarchitectonic studies may identify novel FMUs in the primate p2 alar plate that may give rise to the “newer” thalamic nuclei. The primate thalamus also shows a significant “cell lineage expansion” of GABAergic interneurons. In rodents, these neurons are originated in the midbrain and the forebrain (), but they have not been traced to specific FMUs. Thus, the thalamic expansion in primates compared to rodents may involve the specification of novel FMUs, longer neurogenetic periods, and the expansion of the GABAergic interneuron progenitors in several neuromeres.
Finally, the primate nigrostriatal system “Telodendrion expansion” may be the only possible mechanism to provide dopaminergic innervation to the expanded primate striatum because of the developmental constrains in the neurogenetic capacity of floor and basal plates, as commented in the previous section. The “Telodendrion expansion” mode in the primate nigrostriatal system could be due to the downregulation of repressive signals that inhibit nigrostriatal axon growth (a secondary event of histogenesis). Actually, it has been shown that the downregulation of Zinc finger E-box-binding homeobox 2 (Zeb2) in the rat developing midbrain neurons increases Bone Morphogenetic Proteins (BMP) signaling, which promotes axon growth. Thus, the Zeb2 knockout mouse has normal SNc dopaminergic neurons numbers, but dopaminergic hyperinnervation of the striatum (). Therefore, variations in the expression of transcription factors like Zeb2 could explain the primate nigrostriatal “Telodendrion expansion” mode.
An intriguing question posed by the expansion modes described in the present article is that several alar plate derivatives (cerebral cortex, cerebellum, striatum, pontine nuclei, thalamus) seem to expand in concert along phylogeny. These alar plate derivatives are originated in different neuromeres (Figures 2, 5); some of them are specified by the expression of Otx-2 and others by Hox genes (Figures 12B, D). At what level of gene regulatory networks is the concerted expansion of these alar plate derivatives regulated? Developmental gene regulatory networks are hierarchical (Peter and Davidson, 2015). This means that the generation of spatial gene expression profiles during the early pre- and postgastrular embryos is encoded at the highest level of the networks (1st specification level in Table 2); in a lower level are encoded the spatial gene expression profiles that specify FMUs (2nd and 3rd specification level in Table 2); and, finally, in the lowest level are encoded the gene expression profiles that specify cell types and other secondary events of histogenesis (4th specification level in Table 2). The primate alar plate derivative expansion could be coded in the lower level by coincident independent modifications in the regulation of each alar FMU; alternatively, there could be an intermediate level where regulatory modifications could impact downstream the regulation of secondary events in several alar FMUs.
5 Conclusions
In the present article we have described five different expansion modes of human and non-human primate nervous system parts and traced them back to their corresponding Prosomeric Model FMUs. These modes confirm that neural structures originated in the alar plate can significantly expand in the primate nervous system both quantitatively, by the production of more neurons, and qualitatively, by the expansion of some cell types and, maybe, the specification of novel FMUs. The human cerebral cortex shows a large tangential quantitative (volume and number of neurons) expansion but also a significant qualitative expansion with the appearance of new cytoarchitectonic cortical types; the new types have more neurons in layers II–IV and more GABAergic interneurons originated in pallial and subpallial FMUs. Some alar plate derivatives, like the pontine nuclei, the cerebellar cortex, and the striatum, are “just” quantitatively expanded by the addition of more neurons. Other alar plate derivatives, like the amygdala and the thalamus, show volume expansion in some nuclei and, in the case of the thalamus, the appearance of new nuclei together with an extraordinary expansion of the GABAergic interneuron population. Our analysis also confirms that neural structures originated in the floor and basal plates have severe developmental constrains that do not allow for significant phylogenetic neuron number expansion; thus, the nigrostriatal system is expanded by “Telodendrion expansion” to provide dopaminergic innervation to the enlarged primate striatum. The expansion and branching of telodendrions also probably plays major roles in the diversification and specialization of alar plate neural circuit in primates compared to rodents, as showed for the thalamus (Parent and Parent, 2005).
The expansion modes in primate nervous system structures can be traced back to variations in the primary events of specification (like the specification of novel FMUs) and secondary events of histogenesis (like longer neurogenetic periods, expansion of cell lineages, or axon growth disinhibition) in the corresponding FMUs. Variation in primary events should be encoded in the intermediate level of gene regulatory networks; on the other hand, variation in secondary events should be encoded in the lower levels of gene regulatory networks, although some modifications in intermediate regulatory levels could account for the concerted expansion of primate alar plate derivatives. It must be acknowledged that the speculations advanced in the present article are based on the comparative analysis of primate and rodent adult brains (thus, after the tertiary events of morphogenesis are finalized) and lack experimental confirmation from developmental studies in primate embryos. Such confirmation may be obtained in future studies of the gene regulatory networks of primary and secondary developmental events in each Prosomeric Model FMU in primates and other mammals. These studies could provide the necessary insight to identify the developmental and phylogenetic causal mechanisms of the expansion modes described in the present article.
Statements
Data availability statement
The original contributions presented in the study are included in the article/Supplementary Materials. Further inquiries can be directed to the corresponding author.
Author contributions
MG-C developed the study conception and design. MG-C, SR-C, JZ-D, and IP-S reviewed the literature cited in the text and the figures. SR-C, JZ-D, IP-S, and MG-C assembled the figures. MG-C secured funding. JZ-D contributed to the data curation, formal analysis, visualization, and writing - review and editing. All authors contributed to the article and approved the submitted version.
Funding
This work was supported by a Grant for I+D Projects by the Madrid Government (Comunidad de Madrid-Spain) under the Multiannual Agreement with Universidad Autónoma de Madrid in the line of action encouraging young research doctors, in the context of the V PRICIT (Regional Program of Research and Technological Innovation; grant number SI2/PBG/2020-00014). MAG-C was the recipient of a Beatriz Galindo senior research position in the Faculty of Medicine at Universidad Autónoma de Madrid (BEAGAL18/00098; Spanish Government). JZ-D was the recipient of a Margarita Salas Aid for Requalification at Universidad Autónoma de Madrid (CA1/RSUE/2021-00621; Spanish Ministry of Universities). IP-S was the recipient of a grant from the Chair in Neuroscience UAM-Fundación Tatiana Pérez de Guzmán el Bueno.
Acknowledgments
We thank Dr. Cesar Porrero (Department of Anatomy, Histology and Neuroscience; School of Medicine, Autónoma University of Madrid; Madrid, Spain) for the precious gift of the Nissl-stained mouse brain sections photographed in Figure 8. We also thank Dr. Carmen Cavada (Department of Anatomy, Histology and Neuroscience: School of Medicine, Autónoma University of Madrid; Madrid, Spain) for the precious gift of the Nissl-stained rat, macaque, and human brain sections photographed in Figures 4, 8. The use of human brain tissue was approved by the Ethics Committee for Research of Autónoma University of Madrid (Authorization CEI-104- 2011). We also gratefully acknowledge Dr. Carmen Cavada for giving us access to the microscopes and cameras in her laboratory.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
The author MAG-C declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision.
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Supplementary material
The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmamm.2023.1241573/full#supplementary-material
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Summary
Keywords
genoarchitecture, columnar model, field homology, fundamental morphological unit, histogenesis, morphogenesis, cerebral cortex, rhombic lip
Citation
Ruiz-Cabrera S, Pérez-Santos I, Zaldivar-Diez J and García-Cabezas MÁ (2023) Expansion modes of primate nervous system structures in the light of the Prosomeric Model. Front. Mamm. Sci. 2:1241573. doi: 10.3389/fmamm.2023.1241573
Received
16 June 2023
Accepted
03 October 2023
Published
08 November 2023
Volume
2 - 2023
Edited by
Ruth Benavides-Piccione, Spanish National Research Council (CSIC), Spain
Reviewed by
Muhammad A. Spocter, Des Moines University Osteopathic Medical Center, United States; David M. Feliciano, Clemson University, United States
Updates
Copyright
© 2023 Ruiz-Cabrera, Pérez-Santos, Zaldivar-Diez and García-Cabezas.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Miguel Ángel García-Cabezas, garcia.cabezas@uam.es
Disclaimer
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