ORIGINAL RESEARCH article
Front. Mar. Sci.
Sec. Marine Biology
Volume 12 - 2025 | doi: 10.3389/fmars.2025.1642233
This article is part of the Research TopicPhysiological Processes, Disease Progression, Behavior Change and Population Dynamics of Fish in Response to External Environmental StressesView all 6 articles
Effects of UV filters 2-ethylhexyl 4-methoxycinnamate and benzophenone-3 on in vitro steroidogenesis during oocyte maturation of the longchin goby, Chasmichthys dolichognathus
Provisionally accepted
- 1National Institute of Food and Drug Safety Evaluation, Cheongju-si, Republic of Korea
- 2Pukyong National University, Busan, Republic of Korea
- 3National Institute of Fisheries Science (NIFS), Busan, Republic of Korea
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We investigated the estrogenic effects of 2-ethylhexyl 4-methoxycinnamate (EHMC) and benzophenone-3 (BP-3) on steroidogenesis in maturing oocytes of the longchin goby. Oocytes with 0.77, 0.82 and 0.87 mm diameters were incubated with EHMC (0.5-500 ng/mL) or BP-3 (0.5-500 ng/mL) for 24 h with [³H]17α-hydroxyprogesterone as a precursor. The major steroid metabolites were separated and identified as androstenedione, testosterone (T), estradiol-17β (E2), estrone, and 17,20βdihydroxy-4-pregnen-3-one (17α20βP). E2 metabolite was significantly increased at 5 and 0.5 ng/mL of EHMC in 0.82-mm and 0.87-mm diameter oocytes, respectively. Furthermore, it was increased significantly at 5 ng/mL of BP-3 in the oocytes of 0.87 mm. In addition, 5, 50 and 500 ng/mL of EHMC increased the ratio of E2/17α20βP in the oocytes of 0.82 mm. 0.5 ng/mL of BP-3 increased the ratio of E2/T in the oocytes of 0.87 mm. These results suggest that EHMC and BP-3 have a potential estrogenic activity in the steroidogenic shift process, vitellogenic stage to final maturation stage.
Keywords: estrogen, Benzophenone-3, Estrogenic effects, Longchin goby, maturing oocytes, steroidogenesis, 2-ethylhexyl 4-methoxycinnama
Received: 06 Jun 2025; Accepted: 04 Aug 2025.
Copyright: © 2025 Woo, Baek and Hwang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: In Joon Hwang, National Institute of Fisheries Science (NIFS), Busan, Republic of Korea
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