Abstract
Chronic obstructive pulmonary disease (COPD) is no longer a respiratory disease that predominantly affects men, to the point where the prevalence among women has equaled that of men since 2008, partly due to their increasing exposure to tobacco and to biomass fuels. Indeed, COPD has become the leading cause of death in women in the USA. A higher susceptibility of female to smoking and pollutants could explain this phenomenon. Besides, the clinical presentation appears different among women with more frequent breathlessness, anxiety or depression, lung cancer (especially adenocarcinoma), undernutrition and osteoporosis. Quality of life is also more significantly impaired in women. The theories advanced to explain these differences involve the role of estrogens, smaller bronchi, impaired gas exchange in the lungs and smoking habits. Usual medications (bronchodilators, ICS) demonstrated similar trends for exacerbation prevention and lung function improvement in men and women. There is an urgent need to recognize the increasing burden of COPD in women and therefore to facilitate global improvements in disease management (smoking cessation, pulmonary rehabilitationā¦) in half of the population. Nevertheless, important limitations to the treatment of women with COPD include greater under-diagnosis than in men, fewer spirometry tests and medical consultations. In conclusion there is an urgent need to recognize the increasing burden of COPD in women and therefore to facilitate globally improvements in disease management in this specific population.
COPD Epidemiology
Chronic obstructive pulmonary disease (COPD) is no longer a disease that exclusively affects men as its prevalence represents 9.23% [8.16ā10.36] in men and 6.16% [5.41ā6.95] in women of the whole population (1). In some countries, the prevalence of COPD is even higher in women than in men (2), and its prevalence increases more rapidly in women, particularly in younger women (3). Besides, women are more likely to be diagnosed and considered as asthmatic (4).
Whether gender confers a particular susceptibility to develop COPD has been controversial (5, 6), but there is increasing evidence suggesting that for a given level of risk exposure, women are more susceptible to developing COPD or to have faster disease progression than men (7, 8). For example, female smokers are at greater risk of airflow obstruction than male smokers (9, 10).
The increase in prevalence of COPD among women is also due increased exposure to tobacco and to biomass fuels (11, 12). In addition, specific professional exposure is not well known (13). For example, regular use of chemical disinfectants may lead to COPD development (14) and women with lower cumulative exposure years to aromatic solvents than men have a greater lung function decline than men (15).
Clinical Presentation
In Stable Condition
The clinical manifestations of COPD can differ by gender, with women experiencing worse lung function and health-related quality of life than men.
There is evidence of a higher susceptibility of female to smoking. Among more than 13,000 subjects, Prescott et al. estimated that the excess loss of FEV1 per pack-year of smoking was between 7.4 and 10.5 ml in female smokers compared to 6.0 to 8.4 ml in male smokers (16). The annual decline in lung density is quicker in women (17). Besides, there is a greater prevalence of females among those with early onset of COPD (6).
Women tend to report more symptoms given the same disease severity. For a given airflow obstruction and age, women with COPD more often exhibit anxiety (anxiety score being higher 9.8 vs. 7.1) (18ā20). Quality of life is also more impaired in women (SGRQ scores 50.6 vs. 45.4; p < 0.02) (19). A higher burden of the disease with a higher dyspnea has been confirmed even after matching on age and FEV1 (18, 21, 22). However women are less likely to report cough and sputum (22) but for a given level of airflow obstruction, experience a greater impact on exercise capacity, breathlessness and poorer quality of life (Table 1).
Table 1
| Women | Men | |
|---|---|---|
| Lung function decline | ++ | + |
| Exacerbations | ++ | + |
| Breathlessness | ++ | + |
| Cough/sputum | + | ++ |
| Quality of life | āā | ā |
| Comorbidities | Anxiety, depression, osteoporosis | Cardiovascular diseases |
| Underdiagnosis of COPD | +++ | ++ |
Clinical presentation differentiating COPD expression among men and women.
COPD, Chronic Obstructive Pulmonary Disease. +: a little increased; ++: increased; +++: very increased; ā: decreased.
Comorbidities are also different between men and women in several studies (23, 24) with a higher frequency of anxiety, depression, osteoporosis in women but a lower prevalence of cardiovascular diseases compared to men (25).
Exacerbations
Higher risk of exacerbation is reported among women as compared to men (18, 21, 22). Additionally, the risk of a first moderate or severe exacerbation was estimated to be 17% greater in women than in men (hazard ratio, 1.17; 95% CI, 1.12ā1.23), with a median time to first exacerbation of 504 days for women and 637 days for men. As previously mentioned, COPD starts earlier in women explaining why these differences were more prominent in the younger age group from 40 years to 65 years (Table 1) (26). Moreover, longitudinal data in COPDGene revealed that female sex is independently associated with risk of acute episodes of respiratory disease independent of other relevant covariates (27). Therefore, women, compared with men, seem to be at greater risk for development of COPD and may present with more severe disease. Besides, females have an increased risk of hospitalization for COPD compared with males (RR = 1.5 [1.2; 2.1] to 3.6 [1.4; 9] (16, 28). Further, female representation is increasing among hospitalized COPD exacerbation over time (29). However male gender as compared to female seems to be associated with a poorer prognosis with a higher 30 and 90 day mortality (30).
Treatments
Several limitations exist concerning treatments' response according to gender. First, a bias in physicians' awareness of COPD, which results in a higher rate of mis- or delayed-diagnosis in women with COPD compared with men, potentially leading to suboptimal treatment (31, 32). Although the gender bias in diagnosis is reduced by the use of spirometry, this tool remains underused, particularly in women (33, 34). Second, gendered analyses are dramatically lacking in pharmacologic trials and studies are underpowered for analyses based on sex, particularly when women are underrepresented.
Even if women with COPD are more likely to have interactions with healthcare providers than men (32, 35), they receive fewer classes of medications and non-pharmacologic interventions for COPD than men (22, 33, 36). Paradoxically, male are more likely to receive more than one maintenance drug, especially long-acting anti-muscarinic or dual long acting bronchodilators for COPD (37, 38).
While, smoking cessation is the most important initial step in COPD management, males seem to have higher sustained quit rates at 12 and 36 months. After adjusting on confounding biases, such as educational level, the effect of gender was lost at 12 months but remained significant at 36 months. Besides, specific drugs to help smoking cessation appear to be prescribed more often in women (37). and smoking cessation strategies appear to be more frequently proposed to women (39). This could imply that women have greater difficulty in sustaining long-term abstinence from tobacco than men (40). However there are few studies specifically designed to examine sex-related differences. Some nicotine-replacement therapies may not be as effective in women, in reducing craving less effectively in women than in men, resulting in larger weight gain in females. However, a study showed that bupropion was equally effective in females and males with COPD (41).
Pulmonary rehabilitation is also a key non-pharmacologic intervention for patients with COPD, but most studies enrolled more males than females and no differences have been shown between men and women. However, women seem to report more benefits than men in the dyspnea domain (+0.85 vs. 0.4 unit) and fatigue domain (0.55 vs. 0.3) (42). These benefits and the specific interventions that can maximize benefit for men and women require further research.
Finally in pharmacological trials, women are underrepresented and little is known about gender differences with respect to response to treatment. Post-hoc analyses of clinical trials assessing long-acting bronchodilators have shown similar trends for exacerbation prevention and lung function improvement in men and women (43, 44).
Discussion
Many areas of the effects of gender on COPD pathogenesis, progression, presentation, and responses to treatments are still very poorly understood. Significant differences between countries and exposures influence airway disease development, phenotypes and diagnosis, especially COPD. Interestingly, among a huge cohort of 68,532 individuals within the Medicare Advantage plan, 22.8% had a diagnosis of COPD associated to asthma. Compared with COPD patients without asthma, there was a higher proportion was female (45).
These factors require much more detailed analyses and carefully performed prospective studies are needed to fully assess the effects of treatment in real world settings. In fact, several limitations exist concerning treatments' response according to gender and globally, gendered analyses are dramatically lacking in pharmacologic trials because studies are underpowered for analyses based on sex, particularly when women are underrepresented. The reasons for these observations are incompletely understood but highlight the importance of evaluating sex differences in COPD. There is a great challenge to better understand the impact of gender in the outcomes of COPD.
Conclusion
Chronic obstructive pulmonary disease (COPD) is no longer a respiratory disease that predominantly affects men. Females seem to be more susceptible to the deleterious effects of smoking and have more impaired quality of life, more frequent exacerbations but less cardiovascular comorbidities. There is a need for further work in this area to determine how women with COPD can best be supported. Further research could focus on personalized approaches to achieve optimal treatment in women with COPD.
Publisher's Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Statements
Author contributions
MZ and CR-S made substantial contributions to conception and design, acquisition of data, analysis and interpretation of data, involved in drafting the manuscript or revising it critically for important intellectual content, and gave final approval of the version to be published. Both authors contributed to the article and approved the submitted version.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1.
Ntritsos G Franek J Belbasis L Christou MA Markozannes G Altman P et al . Gender-specific estimates of COPD prevalence: a systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. (2018) 13:1507ā14. 10.2147/COPD.S146390
2.
Mannino DM Buist AS . Global burden of COPD: risk factors, prevalence, and future trends. Lancet. (2007) 370:765ā73. 10.1016/S0140-6736(07)61380-4
3.
Jenkins CR Chapman KR Donohue JF Roche N Tsiligianni I Han MK . Improving the management of COPD in women. Chest. (2017) 151:686ā96. 10.1016/j.chest.2016.10.031
4.
Chapman KR Tashkin DP Pye DJ . Gender bias in the diagnosis of COPD. Chest. (2001) 119:1691ā5. 10.1378/chest.119.6.1691
5.
Buist AS McBurnie MA Vollmer WM Gillespie S Burney P Mannino DM et al . International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet. (2007) 370:741ā50. 10.1016/S0140-6736(07)61377-4
6.
Silverman M Pedersen S Grigg J . Measurement of airway inflammation in children. Introd Am J Respir Crit Care Med. (2000) 162:S1. 10.1164/ajrccm.162.supplement_1.maic-0
7.
Amaral AFS Strachan DP Burney PGJ Jarvis DL . Female smokers are at greater risk of airflow obstruction than male smokers. UK Biobank Am J Respir Crit Care Med. (2017) 195:1226ā35. 10.1164/rccm.201608-1545OC
8.
Han MK Postma D Mannino DM Giardino ND Buist S Curtis JL et al . Gender and chronic obstructive pulmonary disease: why it matters. Am J Respir Crit Care Med. (2007) 176:1179ā84. 10.1164/rccm.200704-553CC
9.
Jordan RE Miller MR Lam KB Cheng KK Marsh J Adab P . Sex, susceptibility to smoking and chronic obstructive pulmonary disease: the effect of different diagnostic criteria. Anal Health Surv Engl Thorax. (2012) 67:600ā5. 10.1136/thoraxjnl-2011-201384
10.
Sorheim IC Johannessen A Gulsvik A Bakke PS Silverman EK DeMeo DL . Gender differences in COPD: are women more susceptible to smoking effects than men?Thorax. (2010) 65:480ā5. 10.1136/thx.2009.122002
11.
Siddharthan T Grigsby MR Goodman D Chowdhury M Rubinstein A Irazola V et al . Association between household air pollution exposure and chronic obstructive pulmonary disease outcomes in 13 low- and middle-income country settings. Am J Respir Crit Care Med. (2018) 197:611ā20. 10.1164/rccm.201709-1861OC
12.
RamĆrez-Venegas A VelĆ”zquez-Uncal M PĆ©rez-HernĆ”ndez R GuzmĆ”n-Bouilloud NE FalfĆ”n-Valencia R Mayar-Maya ME et al . Prevalence of COPD and respiratory symptoms associated with biomass smoke exposure in a suburban area. Int J Copd. (2018) 13:1727ā34. 10.2147/COPD.S156409
13.
Blanc PD Iribarren C Trupin L Earnest G Katz PP Balmes J et al . Occupational exposures and the risk of COPD: dusty trades revisited. Thorax. (2009) 64:6ā12. 10.1136/thx.2008.099390
14.
Dumas O Varraso R Boggs KM Quinot C Zock JP Henneberger PK et al . Association of occupational exposure to disinfectants with incidence of chronic obstructive pulmonary disease among US female nurses. JAMA Netw Open. (2019) 2:e1913563. 10.1001/jamanetworkopen.2019.13563
15.
Alif SM Dharmage S Benke G Dennekamp M Burgess J Perret JL et al . Occupational exposure to solvents and lung function decline: a population based study. Thorax. (2019) 74:650ā8. 10.1136/thoraxjnl-2018-212267
16.
Prescott E Bjerg AM Andersen PK Lange P Vestbo J . Gender difference in smoking effects on lung function and risk of hospitalization for COPD: results from a Danish longitudinal population study. Eur Respir J. (1997) 10:822ā7.
17.
Coxson HO Dirksen A Edwards LD Yates JC Agusti A Bakke P et al . The presence and progression of emphysema in COPD as determined by CT scanning and biomarker expression: a prospective analysis from the ECLIPSE study. Lancet Respir Med. (2013) 1:129ā36. 10.1016/S2213-2600(13)70006-7
18.
Roche N Deslee G Caillaud D Brinchault G Court-Fortune I Nesme-Meyer P et al . Impact of gender on COPD expression in a real-life cohort. Respir Res. (2014) 15:20. 10.1186/1465-9921-15-20
19.
Raherison C Tillie-Leblond I Prudhomme A Taille C Biron E Nocent-Ejnaini C et al . Clinical characteristics and quality of life in women with COPD: an observational study. BMC Womens Health. (2014) 14:31. 10.1186/1472-6874-14-31
20.
Zysman M Burgel PR Court-Fortune I Brinchault-Rabin G Nesme-Meyer P Surpas P et al . Relationship between gender and survival in a real-life cohort of patients with COPD. Respir Res. (2019) 20:191. 10.1186/s12931-019-1154-3
21.
DeMeo DL Ramagopalan S Kavati A Vegesna A Han MK Yadao A et al . Women manifest more severe COPD symptoms across the life course. Int J Chron Obstruct Pulmon Dis. (2018) 13:3021ā9. 10.2147/COPD.S160270
22.
Aryal S Diaz-Guzman E Mannino DM . Influence of sex on chronic obstructive pulmonary disease risk and treatment outcomes. Int J Copd. (2014) 9:1145ā54. 10.2147/COPD.S54476
23.
Henoch I Strang S Lofdahl CG Ekberg-Jansson A . Management of COPD, equal treatment across age, gender, and social situation? A register study. Int J Copd. (2016) 11:2681ā90. 10.2147/COPD.S115238
24.
Ekstrom MP Jogreus C Strom KE . Comorbidity and sex-related differences in mortality in oxygen-dependent chronic obstructive pulmonary disease. PLoS ONE. (2012) 7:e35806. 10.1371/journal.pone.0035806
25.
Bellocchia M Masoero M Ciuffreda A Croce S Vaudano A Torchio R et al . Predictors of cardiovascular disease in asthma and chronic obstructive pulmonary disease. Multidiscip. (2013) 8:58. 10.1186/2049-6958-8-58
26.
Stolz D Kostikas K Loefroth E Fogel R Gutzwiller FS Conti V et al . Differences in COPD exacerbation risk between women and men: analysis from the UK clinical practice research datalink data. Chest. (2019) 156:674ā84. 10.1016/j.chest.2019.04.107
27.
Bowler RP Kim V Regan E . Prediction of acute respiratory disease in current and former smokers with and without COPD. Chest. (2014) 146:941ā50. 10.1378/chest.13-2946
28.
Goto T Yoshida K Faridi MK Camargo CA Hasegawa K . Contribution of social factors to readmissions within 30 days after hospitalization for COPD exacerbation. BMC Pulm Med. (2020) 20:107. 10.1186/s12890-020-1136-8
29.
Molinari N Chanez P Roche N Ahmed E Vachier I Bourdin A . Rising total costs and mortality rates associated with admissions due to COPD exacerbations. Respir Res. (2016) 17:149. 10.1186/s12931-016-0469-6
30.
Johansson G Mushnikov V BƤckstrƶm T Engstrƶm A Khalid JM Wall J et al . Exacerbations and healthcare resource utilization among COPD patients in a Swedish registry-based nation-wide study. BMC Pulm Med. (2018) 18:17. 10.1186/s12890-018-0573-0
31.
Lisspers K Larsson K Janson C StƤllberg B Tsiligianni I Gutzwiller FS et al . Gender differences among Swedish COPD patients: results from the ARCTIC, a real-world retrospective cohort study. NPJ Prim Care Respir Med. (2019) 29:45. 10.1038/s41533-019-0157-3
32.
Martinez CH Raparla S Plauschinat CA Giardino ND Rogers B Beresford J et al . Gender differences in symptoms and care delivery for COPD. J Womens Health. (2012) 21:1267ā74. 10.1089/jwh.2012.3650
33.
Jia G Lu M Wu R Chen Y Yao W . Gender difference on the knowledge, attitude, and practice of COPD diagnosis and treatment: a national, multicenter, cross-sectional survey in China. Int J Copd. (2018) 13:3269ā80. 10.2147/COPD.S176173
34.
Mamary AJ Stewart JI Kinney GL Hokanson JE Shenoy K Dransfield MT et al . Race and gender disparities are evident in COPD underdiagnoses across all severities of measured airflow obstruction. Chron Obstruc Pulmon Dis. (2018) 5:177ā84. 10.15326/jcopdf.5.3.2017.0145
35.
Sundh J Johansson G Larsson K LindĆ©n A Lƶfdahl CG Janson C et al . Comorbidity and health-related quality of life in patients with severe COPD attending Swedish secondary care units. Int J of COPD. (2015) 10:173ā83. 10.2147/COPD.S74645
36.
Lamprecht B Soriano JB Studnicka M Kaiser B Vanfleteren LE Gnatiuc L et al . Determinants of underdiagnosis of COPD in national and international surveys. Chest. (2015) 148:971ā85. 10.1378/chest.14-2535
37.
Bade BC DeRycke EC Ramsey C Skanderson M Crothers K Haskell S et al . Sex differences in veterans admitted to the hospital for chronic obstructive pulmonary disease exacerbation. Ann Am Thorac Soc. (2019) 16:707ā14. 10.1513/AnnalsATS.201809-615OC
38.
Roche N Antoniadis A Hess D Li PZ Kelkel E Leroy S et al . Are there specific clinical characteristics associated with physician's treatment choices in COPD?Respir Res. (2019) 20:189. 10.1186/s12931-019-1156-1
39.
Ć berg J Hasselgren M Montgomery S Lisspers K StƤllberg B Janson C et al . Sex-related differences in management of Swedish patients with a clinical diagnosis of chronic obstructive pulmonary disease. Int J Copd. (2019) 14:961ā9. 10.2147/COPD.S193311
40.
Tsiligianni I Rodriguez MR Lisspers K LeeTan T Infantino A . Call to action: improving primary care for women with COPD. NPJ Primary Care Respir Med. (2017) 27:11. 10.1038/s41533-017-0013-2
41.
Tashkin D Kanner R Bailey W Buist S Anderson P Nides M et al . Smoking cessation in patients with chronic obstructive pulmonary disease: a double-blind, placebo-controlled, randomised trial. Lancet. (2001) 357:1571ā5. 10.1016/S0140-6736(00)04724-3
42.
Moore SM Kramer FM . Women's and men's preferences for cardiac rehabilitation program features. J Cardiopulm Rehabil. (1996) 16:163ā8. 10.1097/00008483-199605000-00003
43.
Wedzicha JA Singh D Tsiligianni I Jenkins C Fucile S Fogel R et al . Treatment response to indacaterol/glycopyrronium versus salmeterol/fluticasone in exacerbating COPD patients by gender: a post-hoc analysis in the FLAME study. Respir Res. (2019) 20:4. 10.1186/s12931-019-0972-7
44.
Tsiligianni I Mezzi K Fucile S Kostikas K Shen S Banerji D et al . Response to Indacaterol/Glycopyrronium (IND/GLY) by Sex in Patients with COPD: A Pooled Analysis from the IGNITE Program. COPD. (2017) 14:375ā81. 10.1080/15412555.2017.1324837
45.
Blanchette CM Gutierrez B Ory C Chang E Akazawa M . Economic burden in direct costs of concomitant chronic obstructive pulmonary disease and asthma in a Medicare Advantage population. J Manag Care Pharm. (2008) 14:176ā85. 10.18553/jmcp.2008.14.2.176
Summary
Keywords
chronic obstructive pulmonary disease (COPD), gender, epidemiology, smoking, perspective
Citation
Zysman M and Raherison-Semjen C (2022) Women's COPD. Front. Med. 8:600107. doi: 10.3389/fmed.2021.600107
Received
28 August 2020
Accepted
29 November 2021
Published
03 January 2022
Volume
8 - 2021
Edited by
Dragana Jovanovic, University of Belgrade, Serbia
Reviewed by
Joanna Julia Domagala-Kulawik, Medical University of Warsaw, Poland; Jun-Jun Yeh, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Taiwan
Updates
Copyright
Ā© 2022 Zysman and Raherison-Semjen.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: MaƩva Zysman maeva.zysman@chu-bordeaux.fr
This article was submitted to Pulmonary Medicine, a section of the journal Frontiers in Medicine
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.