ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1523711
Association between triglyceride-glucose index and cataract among outpatient US adults
Provisionally accepted
- Wenzhou Medical University, Wenzhou, China
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Background: Although numerous studies have associated a higher TyG index with various diseases, there is limited research on its potential link to cataract. This study seeks to investigate the relationship between the TyG index and cataract in the outpatient adult population in the United States.Methods: Our study used NHANES data from the 1999-2008 cycles. We applied weighted multivariate logistic regression to investigate the relationship between the TyG index and cataract in the United States and conducted subgroup analysis to assess the robustness of these associations across different populations.Results: Among 5,433 adults (2,699 [46.8%] male; 2,734 [53.2%] female), 1,038 (15.4%) had cataract. A fully adjusted model (i.e., model 2, see Table 2) showed that the highest quartile array of TyG index (Quartile IV) was positively associated with a higher risk of cataract among men (OR=1.63 (1.10-2.43), P= 0.016). No difference was found in the female population.Conclusions: Our research reveals that the highest quartile array of TyG index (Quartile IV) is associated with a higher risk of cataract among men. This suggests that elevated levels of this index may contribute to the likelihood of developing cataracts, emphasizing the need to consider this metabolic parameter when assessing eye health in males.
Keywords: Cataract, Triglyceride-glucose (TyG) index, Cross-sectional study, national Health and Nutrition Examination Survey (NHANES), Outpatient US Adults
Received: 06 Nov 2024; Accepted: 02 May 2025.
Copyright: © 2025 Jin, Huang, Gao and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jianmin Zhu, Wenzhou Medical University, Wenzhou, China
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