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ORIGINAL RESEARCH article

Front. Med.

Sec. Obstetrics and Gynecology

Volume 12 - 2025 | doi: 10.3389/fmed.2025.1555883

This article is part of the Research TopicAdvances in New Biomarkers for the Diagnosis and Therapy of Gynaecological TumoursView all 3 articles

Tumor-Infiltrating Lymphocytes are the Key Determinants of Pathological Features associated Associated with BRCA Mutation Status in High-Grade Serous Ovarian Carcinoma

Provisionally accepted
Dang H. Nguyen-PhanDang H. Nguyen-Phan1,2Tin DangTin Dang2Anh N. AnhAnh N. Anh2Loc T. H. HuynhLoc T. H. Huynh2Phuong T. B. NguyenPhuong T. B. Nguyen2Vu Q. TranVu Q. Tran2Hanh T. T. NgoHanh T. T. Ngo3*Thao T. P. DoanThao T. P. Doan4Tu A. ThaiTu A. Thai2Chien-Chin ChenChien-Chin Chen5,6,7,8*
  • 1Department of Pathology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Vietnam
  • 2Department of Pathology, Ho chi minh city oncology hospital, Ho Chi Minh City, Vietnam
  • 3Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam
  • 4Ho Chi Minh City University Medical Center, Ho Chi Minh City, Vietnam
  • 5Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan
  • 6Department of Pathology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chiayi city, Taiwan
  • 7Department of Cosmetic Science, Chia Nan University of Pharmacy and Science, Tainan, Tainan County, Taiwan
  • 8Department of Biotechnology and Bioindustry Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Tainan County, Taiwan

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High-grade serous ovarian carcinoma (HGSOC), is an aggressive cancer associated with pathogenic BRCA variants, causing causes genomic instability and sensitivity to poly (ADP-ribose) polymerase inhibitors. Identifying pathogenic BRCA variants is crucial for the treatment of HGSOC; however, genetic testing is costly expensive and time-consuming. This study aimed to explore pathological features, particularly the presence of tumor-infiltrating lymphocytes (TILs), as potential surrogates to streamline patient selection for genetic testing.

Keywords: BRCA, Histology, high-grade serous ovarian carcinoma, Mitosis, Ovary, tumorinfiltrating lymphocyte

Received: 05 Jan 2025; Accepted: 29 Apr 2025.

Copyright: © 2025 Nguyen-Phan, Dang, Anh, Huynh, Nguyen, Tran, Ngo, Doan, Thai and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Hanh T. T. Ngo, Ho Chi Minh City University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam
Chien-Chin Chen, Doctoral Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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