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ORIGINAL RESEARCH article

Front. Med.

Sec. Nuclear Medicine

Volume 12 - 2025 | doi: 10.3389/fmed.2025.1581487

This article is part of the Research TopicRecent developments in artificial intelligence and radiomicsView all 5 articles

Multi-Class Segmentation of Knee MRI Based on Hybrid Attention

Provisionally accepted
Yuhang  XiangYuhang Xiang1Xinglin  ZhangXinglin Zhang2Tao  MengTao Meng2,3*Tao  ChenTao Chen4,5*
  • 1Gannan Medical University, Ganzhou, China
  • 2Shanghai Medical Image Insights Intelligent Technology Co., Ltd., Shanghai, China
  • 3Jiangxi Rimag Group Co., Ltd., Nanchang, China
  • 4Big Data Research Lab, University of Waterloo, Waterloo, Canada
  • 5Labor and Worklife Program, Harvard University, Cambridge, United States

The final, formatted version of the article will be published soon.

Accurate segmentation of knee MRI images is crucial for the diagnosis and treatment of degenerative knee disease and sports injuries. However, existing multi-class segmentation methods tend to ignore small targets and are challenged by class imbalance, resulting in suboptimal segmentation performance. This paper applies hybrid attention and multi-scale feature extraction to the problem of multi-class segmentation of knee MRI images and innovates the classic U-Net architecture. Firstly, we propose a Hierarchical Feature Enhancement Fusion (HFEF) module, which is integrated into both the skip connections and the bottleneck layer. This module captures channel and spatial information at multiple levels, enabling the model to efficiently combine local and global features. Secondly, we introduce the Atrous Squeeze Attention (ASA) module, which enables the model to focus on multi-scale features and capture long-range dependencies, thereby improving the segmentation accuracy of complex multi-class structures.Lastly, the loss function is optimized to address the challenges of class imbalance and limited data. The improved loss function enhances the model's ability to learn underrepresented classes, thus enhancing the overall segmentation performance. We evaluated our method on a knee joint MRI dataset and compared it with U-Net. HASA-ResUNet achieved a 12.12% improvement in Intersection over Union (IoU) for the low-frequency and small-sized class (Anterior cruciate ligament) and an overall improvement of 3.32% in mIoU.

Keywords: Medical image segmentation, deep learning, attention mechanism, Knee, MRI

Received: 22 Feb 2025; Accepted: 19 May 2025.

Copyright: © 2025 Xiang, Zhang, Meng and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Tao Meng, Jiangxi Rimag Group Co., Ltd., Nanchang, China
Tao Chen, Big Data Research Lab, University of Waterloo, Waterloo, Canada

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