ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1589605
This article is part of the Research TopicAdvances in Understanding and Managing Systemic Sclerosis-Associated Interstitial Lung Disease: Bridging Prognostic Biomarkers to Therapeutic InnovationsView all 3 articles
The Association Between High Atherogenic Index of Plasma and Impaired Lung Function: A Population-Based Study
Provisionally accepted
- Zhujiang Hospital, Southern Medical University, Guangzhou, China
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Objective: Although AIP is a recognized cardiovascular risk marker, its association with pulmonary function and sex-specific differences remains unclear. This study investigated whether elevated AIP is independently associated with reduced lung function and examined potential sex-specific patterns.Methods: Data from 4,565 participants in the NHANES 2007-2012 dataset were analyzed using a cross-sectional design. AIP served as the exposure variable, with five lung function metrics (including FEV₁, FVC, and FEV₁/FVC ratio) as outcomes.Weighted multiple linear regression, threshold effect analysis, subgroup comparisons, and XGBoost modeling were performed to assess associations.Results: Multivariable regression showed a significant negative association between AIP and FEV₁ (β=-121.3 mL/unit, p<0.001) and FVC (β=-147.1 mL/unit, p<0.001), with no significant link to FEV₁/FVC ratio. Subgroup analysis revealed a U-shaped nonlinear association in females, with inflection points at AIP values of 0.77 (FEV₁) and 0.78 (FVC), beyond which declines in lung function plateaued. Males exhibited a consistent negative correlation across all AIP levels.Elevated AIP is independently associated with reduced lung function, particularly nonlinear effects in females. These findings support AIP as a potential adjunct marker for pulmonary function assessment in clinical practice.
Keywords: Atherogenic index of plasma, NHANES, Lung function, Cross-sectional study, nonlinear association
Received: 07 Mar 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Yang, Wu, Chen, Li, Zhu, Zhang, Li, Huang and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Liang Yang, Zhujiang Hospital, Southern Medical University, Guangzhou, China
Qunqing Chen, Zhujiang Hospital, Southern Medical University, Guangzhou, China
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