CASE REPORT article
Front. Med.
Sec. Dermatology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1594640
Case Report: Secukinumab for the treatment of severe psoriasis accompanied by hereditary hemochromatosis
Provisionally accepted
- The First Affiliated Hospital of Ningbo University, Ningbo, China
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There are several comorbidities associated with psoriasis, including some genetic disorders such as hereditary hemochromatosis, which presented with organ damage secondary to iron overload .Herein, we report a 38-year-old Chinese man with hereditary hemochromatosis, who received secukinumab for treatment of severe psoriasis. Follow-up after 3 months showed that the patient's lesions had almost resolved and maintained for 2 years without any side effects. Patients with psoriasis and hereditary hemochromatosis have limited treatment options due to the effects of iron overload on the liver, particularly by potentially increasing the risk of hepatocellular carcinoma.Interleukin-17A (IL-17A) inhibitors, including the secukinumab we employed, may benefit these patients.
Keywords: Psoriasis, hereditary hemochromatosis, secukinumab, Liver function, IL-17A
Received: 16 Mar 2025; Accepted: 16 Jul 2025.
Copyright: © 2025 Yu, Lu, Fan, WAng and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bingjiang Lin, The First Affiliated Hospital of Ningbo University, Ningbo, China
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