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ORIGINAL RESEARCH article

Front. Med.

Sec. Precision Medicine

Volume 12 - 2025 | doi: 10.3389/fmed.2025.1596335

This article is part of the Research TopicArtificial Intelligence Algorithms and Cardiovascular Disease Risk AssessmentView all articles

Explainable AI-Driven Intelligent System for Precision Forecasting in Cardiovascular Disease

Provisionally accepted
Dr Anas  BilalDr Anas Bilal1Abdulkareem  AlzahraniAbdulkareem Alzahrani2Khalid  AlmohammadiKhalid Almohammadi3Muhammad  SaleemMuhammad Saleem4Muhammad  Sajid FarooqMuhammad Sajid Farooq5Raheem  SarwarRaheem Sarwar6*
  • 1Hainan Normal University, Haikou, China
  • 2Al Baha University, Al Bahah, Saudi Arabia
  • 3University of Tabuk, Tabuk, Tabuk, Saudi Arabia
  • 4Minhaj University Lahore, Lahore, Punjab, Pakistan
  • 5NASTP Institute of Information Technology, Lahore, Punjab, Pakistan
  • 6Manchester Metropolitan University, Manchester, North West England, United Kingdom

The final, formatted version of the article will be published soon.

Cardiovascular diseases (CVDs) are complex and affect a large part of the world's population; early accurate and timely prediction is also complicated. Typically, predicting CVDs involves using statistical models and other forms of standard machine learning. Although these methods offer some level of prediction, their black-box nature severely hinders the ability of the healthcare professional to trust and use the predictions. The following are some of the challenges that Explainable Artificial Intelligence (XAI) may solve since it can give an understanding of the decision-making system of AI to build confidence and increase usability. This research introduced an intelligent forecasting system for cardiovascular events using XAI and addressed the limitations of traditional methods. This proposed system incorporates advanced machine learning algorithms integrated with XAI to examine a dataset comprising 308,737 patient records with features including age, BMI, blood pressure, cholesterol levels, and lifestyle factors. This dataset was sourced from the Kaggle Cardiovascular Disease dataset. Incorporating XAI offers an understandable explanation so that the healthcare professional can understand and make the AI-driven prediction trustworthy enough to improve the decision-making of treatment and care delivery for the patients. The simulation results of the proposed system provide better results than those of the previously published research works in terms of 91.94% accuracy and 8.06% miss rate. This proposed system makes it clear that XAI has the potential to significantly improve cardiovascular healthcare by enhancing transparency, reliability, and the quality of patient care.

Keywords: Cardiovascular Diseases, Explainable artificial intelligence, Electronic Medical Records, machine learning, Shap, Lime

Received: 19 Mar 2025; Accepted: 12 Jun 2025.

Copyright: © 2025 Bilal, Alzahrani, Almohammadi, Saleem, Farooq and Sarwar. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Raheem Sarwar, Manchester Metropolitan University, Manchester, M15 6BH, North West England, United Kingdom

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