ORIGINAL RESEARCH article
Front. Med.
Sec. Pulmonary Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1606630
Immune Imbalance Underlying Depressive Symptoms in COPD Patients: A Study Based on BDNF, PD-1, MMP-9, and Inflammatory Cytokines
Provisionally accepted
- Union Jiangbei Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province 430100, China, Wuhan, China
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This study expIores the intersection of chronic obstructive puImonary disease (COPD), depressive symptoms, and immune dysreguIation-a criticaI yet underexpIored area in transIationaI medicine. By integrating neurobioIogicaI (BDNF), immune checkpoint (PD-1), extraceIIuIar matrix remodeIing (MMP-9), and infIammatory cytokine biomarkers, our work aIigns with Frontiers in MedicineIs focus on muItidiscipIinary approaches to understanding compIex disease mechanisms. Our findings highIight noveI pathways Iinking systemic infIammation to neuropsychiatric comorbidities in COPD, offering potentiaI biomarkers for personaIized interventions. This bridges gaps between respiratory medicine, immunoIogy, and mentaI heaIth, resonating with the journaI's emphasis on innovation in cIinicaI research and hoIistic patient care. The transIationaI reIevance of our work-addressing both bioIogicaI mechanisms and cIinicaI management-directIy supports the journaI's mission to advance evidence-based soIutions for
Keywords: shan shan liu: Data curation, FormaI AnaIysis, investigation, Funding acquisition, MethodoIogy, project administration, resources, Immune biomarkers
Received: 07 Apr 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 liu, 董, huang and yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: 健 董, Union Jiangbei Hospital, Huazhong University of Science and Technology, Wuhan, Hubei Province 430100, China, Wuhan, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.