CASE REPORT article
Front. Med.
Sec. Gastroenterology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1640436
This article is part of the Research TopicThe Pathogenesis and Treatment Progress of Intestinal DiseasesView all 12 articles
Idiopathic AA Amyloidosis Presenting with Initial Abdominal Pain: A Case Report and Literature Review
Provisionally accepted
- Department of gastroenterology, The second Xiangya Hospital, Central South University, Changsha, China
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Amyloidosis is a rare disease, often secondary to chronic inflammation or autoimmune disorders, with an unclear etiology in some cases. Herein, we report a 67year-old male patient presenting with recurrent abdominal pain and multi-system involvement. The diagnosis of AA amyloidosis was confirmed by Congo red staining of small intestinal mucosal and bone marrow biopsies. Despite comprehensive screening, no definite etiology was identified. This case highlights that amyloidosis should be considered in patients with unexplained abdominal pain and multisystem abnormalities, and early tissue biopsy is crucial for diagnosis.
Keywords: Abdominal Pain, AA amyloidosis, diagnosis, etiology, Serum Amyloid A Protein, Gastrointestinal Diseases
Received: 03 Jun 2025; Accepted: 23 Jul 2025.
Copyright: © 2025 Xia, Deng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Feihong Deng, Department of gastroenterology, The second Xiangya Hospital, Central South University, Changsha, China
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