CASE REPORT article
Front. Med.
Sec. Nuclear Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1653232
The Alzheimer's Paradox: A Clinically Stable Amnestic Syndrome with Full Biomarker Positivity and Minimal Imaging Evidence
Provisionally accepted
Anna-Chloé Balageas1
Johnny Vercouillie2
Nicolas ARLICOT1,2
Anne-Claire Dupont1
Maria-Joao Santiago Ribeiro1,2*- 1Centre Hospitalier Regional Universitaire de Tours, Tours, France
- 2Universite de Tours, Tours, France
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We report the case of a 75-year-old patient with a clinically isolated and stable amnestic syndrome over fifteen years, despite a cerebrospinal fluid (CSF) profile strongly consistent with Alzheimer's disease (AD). Serial PET imaging over two years showed only limited amyloid accumulation, no significant tau deposition, no hypometabolism, and no neuroinflammation. This case illustrates a striking dissociation between biomarker positivity and clinical progression, raising important questions about individual resilience and the prognostic value of AD biomarkers in isolation.
Keywords: PET imaging, MCI (mild cognitive impairment), Alzheimer, Neuroimaging, biomarker
Received: 24 Jun 2025; Accepted: 29 Jul 2025.
Copyright: © 2025 Balageas, Vercouillie, ARLICOT, Dupont and Santiago Ribeiro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Maria-Joao Santiago Ribeiro, Centre Hospitalier Regional Universitaire de Tours, Tours, France
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