CASE REPORT article
Front. Med.
Sec. Pathology
Dendritic fibromyxolipoma of the male breast:case report and literary review
Provisionally accepted
- Affiliated Hospital of Zunyi Medical University, Zunyi, China
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Background: Dendritic fibromyxolipoma (DFML) represents a benign lipomatous tumor. Its rarity and distinctive morphology can lead to misinterpretation of other mesenchymal malignancies, which may result in unnecessary aggressive treatments. Case presentation: A 39-year-old male presented with a left mammary mass that had been noticed one year earlier. Chest computed tomography identified a nodule characterized by fat density in the left mammary region. The initial clinical impression was gynecomastia. A local excision of the left mammary mass was subsequently performed. Histopathological analysis confirmed the diagnosis of DFML. Post-surgical follow-up over 38 months showed no recurrence. Conclusion: DFML is a benign lipomatous tumor with unique morphological features. Complete surgical excision typically leads to no recurrence. This report documents the first known instance of DFML in the mammary gland of a male patient. Furthermore, an analysis of 95 previously documented cases of DFML was conducted. It is strongly advocated that the World Health Organization reclassify DFML as a mucinous subtype of spindle cell lipoma. This reclassification would improve the understanding of DFML and help avoid unnecessary aggressive treatments due to misdiagnosis as a malignancy.
Keywords: dendritic, fibromyxolipoma, Differential, diagnosis, Mammary, Pathological, Characteristics, review
Received: 25 Aug 2025; Accepted: 14 Nov 2025.
Copyright: © 2025 Luo, Tian, Xu and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shuai Luo, 1421227850@qq.com
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