ORIGINAL RESEARCH article
Front. Med.
Sec. Geriatric Medicine
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1654448
Serum VEGF and ANGPT1 as angiogenesis markers may predict the outcomes of older adults with hip fractures
Provisionally accepted
- Nanyang Second General Hospital, Nanyang, China
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Objective: This study aims to investigate the potential of serum Vascular Endothelial Growth Factor (VEGF) and Angiopoietin 1 (ANGPT1) as angiogenesis markers to predict the outcomes of older adults with hip fractures. Methods: An observational study was conducted at the Emergency Trauma Center of Nanyang Second People's Hospital. Serum VEGF and ANGPT1 were measured on the first morning after surgery. Patients were followed up for one year to assess survival status and the ability to walk freely at 3, 6, and 12 months post-surgery. Receiver operating characteristic (ROC) curves were constructed to determine the predictive power of these markers, and propensity score matching (PSM) was performed to account for confounding factors. Multivariate Cox regression and logistic regression models were used to further analyze the prognostic roles of these markers. Results: The study cohort included 380 patients, with a mean age of 75.71 ± 8.58 years and a mortality rate of 17.11% within one year. Kaplan-Meier survival analysis revealed that low levels of VEGF and ANGPT1 were significantly associated with decreased survival probability. Multivariate Cox regression models indicated that low VEGF and ANGPT1 were independent risk factors for one-year mortality, while ANGPT2 did not show significant prognostic value. Conclusion: Elevated serum levels of VEGF and ANGPT1 are associated with improved outcomes in older adults with hip fractures, highlighting the importance of angiogenesis in fracture healing.
Keywords: VEGF, ANGPT1, ANGPT2, Hip fracture, Outcome
Received: 26 Jun 2025; Accepted: 24 Sep 2025.
Copyright: © 2025 Yao, Xing, Zhao, Fan and Chu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qingbo Chu, 13721809268@163.com
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