ORIGINAL RESEARCH article
Front. Med.
Sec. Obstetrics and Gynecology
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1656391
This article is part of the Research TopicMaternal Metabolic Health: From Preconception to PostpartumView all 17 articles
Clinical Features and Outcomes of Pregnancies Complicated by Coexisting Gestational Diabetes and Hypertensive Disorders
Provisionally accepted
- Obstetrical Department, Dongyang Hospital of Wenzhou Medical University, Dongyang, China
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Background: Gestational diabetes mellitus (GDM) and hypertensive disorder complicating pregnancy (HDP) share pathophysiological mechanisms that increase the risk for adverse maternal and neonatal outcomes. However, their combined impact remains underexplored. Objective: To assess the clinical characteristics, therapeutic interventions, and maternal–fetal outcomes in pregnancies complicated by bothGDM and HDP. Methods: A retrospective study was conducted involving 82 women with GDM complicated by HDP and 118 healthy pregnant controls. Clinical parameters, mode of delivery, and pregnancy outcomes were compared between groups. Logistic regression analysis was performed to identify independent predictors of GDM complicated by HDP. Results: Women with GDM complicated by HDP exhibited significantly higher pre-pregnancy weight, body mass index (BMI), fasting blood glucose, triglycerides, and high-density lipoprotein (HDL) cholesterol compared with healthy controls (P < 0.05). Logistic regression identified these variables as independent predictors of GDM + HDP (P < 0.001). The GDM + HDP group also had higher rates of cesarean delivery and adverse pregnancy outcomes. Individualized treatment targeting glycemic and blood pressure control significantly improved metabolic parameters and reduced the incidence of complications (P < 0.05). Conclusion: Pre-pregnancy metabolic factors, including BMI, fasting blood glucose, triglycerides, and HDL cholesterol, are strong predictors of GDM complicated by HDP. Early identification and individualized management of these high-risk pregnancies can effectively reduce adverse maternal and neonatal outcomes.
Keywords: gestational diabetes mellitus, Pregnancy induced hypertension, Adverse pregnancyoutcome, Clinical Characteristics, Metabolic predictors
Received: 30 Jun 2025; Accepted: 02 Oct 2025.
Copyright: © 2025 Du, Jia, Bo and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shunlan Du, 13758953638@wmu.edu.cn
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