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ORIGINAL RESEARCH article

Front. Med.

Sec. Regulatory Science

Global Trends in e-Labeling: A Comprehensive Geographical Perspective

Provisionally accepted
Agnès Dangy-CayeAgnès Dangy-Caye1Valentin LebretonValentin Lebreton2Rebecca LumsdenRebecca Lumsden3Sabine FaberSabine Faber4Ana CavalliAna Cavalli5Maria De LuciaMaria De Lucia6Sima DesaiSima Desai2*
  • 1Sanofi (France), Gentilly, France
  • 2Sanofi US, Morristown, United States
  • 3sanofi UK, Reading, United Kingdom
  • 4Sanofi DE, Berlin, Germany
  • 5Sanofi, São Paulo, Brazil
  • 6Sanofi, Panama city, Panama

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This study presents a comprehensive analysis of e-labeling adoption for medicinal products worldwide. Electronic Product Information (ePI) makes available the most up to date approved medicinal product information on an electronic platform, accessed through a code or a locator included on the product packaging. Electronic Product Information can be viewable in different formats from simple ones (pdf file) to a more structured form allowing true digitalization (html/xml). The data were recovered based on internal company survey data from 182 countries collected between January 2, 2024, and April 7, 2025. Based on data from 182 countries where the company operates, the findings reveal diverse implementation stages across regions, with some countries having fully incorporated e-labeling into their regulations while others explore initial pilot programs. The hybrid approach combining printed leaflets and electronic product information with some possibilities of removing the printed leaflet emerges as the predominant model in pilot studies, though most countries still mandate paper documentation. QR codes on outer packaging (74.7%) and PDF format (67.3%) represent the most widely adopted technical solutions for the implementation of e-labeling. E-labeling offers substantial benefits including real-time information updates, environmental sustainability, and supply chain improvements. Cross-regional knowledge exchange and multi-stakeholder collaboration will be essential to accelerate harmonized global e-labeling adoption.

Keywords: e-labeling initiative, e-labeling pilot, regulation, Paperless, implementation, E-labeling, Electronic product information, EPI

Received: 09 Jul 2025; Accepted: 13 Nov 2025.

Copyright: © 2025 Dangy-Caye, Lebreton, Lumsden, Faber, Cavalli, De Lucia and Desai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Sima Desai, sima.desai@sanofi.com

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material