ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
This article is part of the Research TopicOutcome of Sepsis and Prediction of Mortality Risk - Volume IIView all 17 articles
Diagnostic value and prognostic significance of microRNA-210, serum creatinine, neutrophil gelatinase-associated lipocalin, blood urea nitrogen, cystatin C and Sequential Organ Failure Assessment scores in patients with sepsis-associated acute kidney injury
Provisionally accepted
- Shengli Oilfield Central Hospital, Dongying, China
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Background: Sepsis-associated acute kidney injury is common in critically ill patients and is strongly associated with adverse outcomes. Objective: To explore the diagnostic value and prognostic significance of microRNA (miRNA) miR-210, serum creatinine (Scr), neutrophil gelatinase-associated lipocalin (NGAL), blood urea nitrogen (BUN), cystatin C (CysC) and Sequential Organ Failure Assessment (SOFA) scores in patients with sepsis-associated acute kidney injury. Design: This was a retrospective study. Setting: This study was performed in Department of Intensive Care Unit, Shengli Oilfield Central Hospital. Participants: A total of 81 sepsis patients who were treated in our hospital from April to November of 2021 were chosen and divided into two groups according to whether acute kidney injury was combined. Interventions: The levels of miR-210, Scr, NGAL, BUN, CysC and SOFA scores were detected, and ROC curve was implemented to assess the diagnostic value. The risk factors influencing prognosis were assessed by binary Logistic regression. Primary Outcome Measures: (1) levels of miR-210, Scr, NGAL, BUN, CysC and SOFA scores (2) diagnostic value of miR-210, Scr, NGAL, BUN, CysC and SOFA scores. (3) risk factors influencing prognosis of patients with sepsis-associated acute kidney injury. Results: Compared with sepsis patients, levels of miR-210, Scr, NGAL, BUN, CysC and SOFA scores in patients with sepsis-associated acute kidney injury were elevated (P<0.001). ROC curve displayed that miR-210 harbored the highest diagnostic value in patients with sepsis-associated acute kidney injury, with an AUC of 0.913, sensitivity and specificity of 92.21% and 91.37%, separately (P<0.001). The expressions of miR-210, NGAL, CysC and SOFA scores in the dead patients were significantly elevated compared to the survival cases (P<0.05). MiR-210 levels and SOFA scores affected the prognosis of patients with sepsis-associated acute kidney injury. Conclusion: Our study demonstrated that miR-210, Scr, NGAL, BUN, CysC and SOFA scores had significant diagnostic value in patients with sepsis-associated acute kidney injury, and miR-210 and SOFA scores had good prognostic value for patients with sepsis-associated acute kidney injury.
Keywords: Blood Urea Nitrogen, Cystatin C, MicroRNA-210, Neutrophil gelatinase-associated lipocalin, Sepsis-associated acute kidney injury, Sequential organ failure assessment scores, serum creatinine
Received: 23 Jul 2025; Accepted: 03 Dec 2025.
Copyright: © 2025 Zhang, Zhang, Liu, Qiao and Fan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Lujun Qiao
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