CASE REPORT article
Front. Med.
Sec. Pathology
Splenic B-cell lymphoma/leukemia with prominent nucleoli and spontaneous splenic rupture: a case report and literature review
Provisionally accepted
- 1Department of the Third General Surgery, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO.1 People’s Hospital, Jiujiang, China
- 2Department of Imaging, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO.1 People’s Hospital, Jiujiang, China
- 3Department of Pathology, Jiujiang City Key Laboratory of Cell Therapy, Jiujiang NO.1 People’s Hospital, Jiujiang, China
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An 80-year-old man was admitted to our hospital for recurrent chest discomfort and shortness of breath over the past 2 years, with symptoms exacerbated by back pain over the past 3 days. The patient had a history of multiple comorbidities. Physical examination on admission revealed grade III splenomegaly. Peripheral blood tests revealed a white blood cell count of 27.03 × 10⁹/L, a lymphocyte percentage of 62.40%, and an absolute lymphocyte count of 16.87 × 10⁹/L. During hospitalization, the patient's blood pressure suddenly dropped, and he developed shock. Computed tomography scan confirmed a rupture at the upper pole of the spleen, requiring emergency surgical exploration. Intraoperatively, the splenic rupture site was identified, and substantial intraperitoneal hemorrhage was noted. Therefore, total splenectomy was performed. The patient's postoperative recovery was initially uneventful; however, chemotherapy was not administered due to poor physical status. Postoperative pathological examination, bone marrow smear, and flow cytometry analysis confirmed the diagnosis of splenic B-cell lymphoma/leukemia with prominent nucleoli (SBLPN). SBLPN is an extremely rare splenic B-lymphocyte neoplasm, with a small number of cases reported in the current literature.
Keywords: case report, Emergency surgery, SplenicB-cell lymphoma/leukemia with prominent nucleoli (SBLPN), Splenomegaly, Spontaneous splenic rupture
Received: 26 Aug 2025; Accepted: 11 Dec 2025.
Copyright: © 2025 RIWei, Yun and Haoru. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Liu Haoru
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