CASE REPORT article
Front. Med.
Sec. Hepatobiliary Diseases
Volume 12 - 2025 | doi: 10.3389/fmed.2025.1695670
Case Report: Cerebral Lipiodol Embolism in the Guangxi Zhuang Autonomous Region, Southwest China
Provisionally accepted
- Guangxi University of Science and Technology First Affiliated Hospital, Liuzhou, China
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Purpose: This study aims to provide insights into the rare occurrence of cerebral Lipiodol embolism following transcatheter arterial chemoembolization (TACE) in treating hepatocellular carcinoma (HCC). By analyzing a specific case, this research seeks to enhance clinical understanding of the pathogenesis, manifestations, and management strategies for this complication, ultimately improving patient outcomes. Background: Cerebral Lipiodol embolism is an infrequent yet severe complication of TACE, a standard treatment for unresectable HCC. The embolism occurs when iodized oil, used during the procedure, inadvertently enters the cerebral circulation, often due to arteriovenous shunts associated with liver tumors. Despite TACE's widespread use, awareness and understanding of this rare complication remain limited, necessitating further investigation to mitigate risks and improve patient safety. Case Presentation: A 64-year-old male with multiple HCCs and portal vein invasion underwent TACE involving iodized oil and chemotherapy agents. Post-procedure, the patient exhibited neurological deficits, including decreased consciousness and right-sided weakness. Imaging confirmed cerebral Lipiodol embolism. Despite gradual neurological improvement, the patient continued to experience significant right-sided weakness, highlighting the long-term impacts of this complication. Conclusion: Cerebral Lipiodol embolism, though rare, poses significant risks during TACE. Early detection through careful imaging and precautionary measures, such as managing Lipiodol injection volumes and speeds, are crucial. Enhanced clinical awareness and intervention strategies can prevent Lipiodol from entering systemic circulation, reducing the incidence of this severe complication.
Keywords: Cerebral lipiodol embolism, Transcatheter arterial chemoembolization, Hepatocellular Carcinoma, neurological complications, interventional radiology
Received: 30 Aug 2025; Accepted: 21 Oct 2025.
Copyright: © 2025 Le, Huang, Mao, Chen, Mo and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wu-Xiao Wei, 853918047@qq.com
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