CASE REPORT article
Front. Med.
Sec. Pulmonary Medicine
This article is part of the Research TopicBridging Tradition and Future: Cutting-edge Exploration and Application of Artificial Intelligence in Comprehensive Diagnosis and Treatment of Lung DiseasesView all 12 articles
Primary mucinous sarcoma of the lung with EWSR1 translocation:a case report
Provisionally accepted
- The Second People's Hospital of Hefei, Hefei, China
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Primary pulmonary myxoid sarcoma (PPMS) is an extremely rare lung sarcoma with a low incidence. It is a low-grade malignant tumor with histological and molecular features similar to those of extranodal myxoid chondrosarcoma. To date, it has been reported less frequently.We report a case of primary mucinous sarcoma of the lung with EWSR1 translocation, which was definitively diagnosed by bronchoscopic biopsy. Biopsy tissues were tested for pathology, immunohistochemistry, and molecular pathology. Additionally, fluorescence in situ hybridisation was performed using an EWSR1 breakthrough probe.The patient's left common branch was obstructed by a neoplasm, which was identified during bronchoscopy. A tracheoscopic circling procedure was then performed. The patient underwent a small-incision sleeve resection of the lower lobe of the left lung and lymph node dissection with the assistance of video-assisted thoracic surgery (VATS) under general anesthesia. The patient had a good postoperative recovery, and a follow-up chest CT at 2 months after the operation showed no signs of recurrence.
Keywords: Primary mucinous sarcoma of the lung, EWSR1 gene translocation, Diagnostic Imaging, Computedtomography, Bronchoscopy
Received: 14 Sep 2025; Accepted: 21 Nov 2025.
Copyright: © 2025 Xu, Yin, Wang, Wang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yongsheng Wang, wangyongshengah@163.com
Xiaoqiong Wang, xiaoqiongwang1220@163.com
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