SYSTEMATIC REVIEW article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
This article is part of the Research TopicData Science in Anesthesiology and Intensive CareView all 8 articles
Effects of EEG-Based Monitoring of Depth of Anesthesia on Postoperative Delirium, Cognitive Dysfunction, and Long-Term Neurocognitive Outcomes: A Meta-Analysis
Provisionally accepted
Xiaochen Huang
Fei Fei*- The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China
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Objective: To evaluate the impact of monitoring depth of anesthesia on postoperative delirium, long-term cognitive function, and patient satisfaction through a comprehensive meta-analysis. Methods: We conducted a systematic review and meta-analysis of studies that assessed the effects of depth of anesthesia monitoring on various postoperative outcomes. Studies were identified through electronic databases, and data were extracted on the duration of anesthesia, early postoperative Mini-Mental State Examination (MMSE) scores, incidence of postoperative delirium, long-term neurocognitive disorders, and patient satisfaction. Pooled standardized mean differences (SMD) and relative risks (RR) were calculated using random-effects models. Heterogeneity was assessed using I² statistics, and publication bias was evaluated using funnel plots and Egger's test. Results: A total of 17 studies were included, encompassing 5684 patients. Monitoring depth of anesthesia did not significantly affect the duration of anesthesia or early postoperative MMSE scores. Similarly, no significant difference was observed in the incidence of postoperative delirium before discharge. However, a significant reduction in the incidence of postoperative neurocognitive disorder was noted in long-term follow-up. No significant differences were found in patient satisfaction. High heterogeneity was observed in some analyses, indicating variability across studies. Conclusion: Monitoring depth of anesthesia appears to have a protective effect against long-term neurocognitive disorders but does not significantly impact short-term cognitive function, delirium incidence, or patient satisfaction. These findings suggest that depth of anesthesia monitoring may be particularly beneficial in high-risk patient populations.
Keywords: Depth of anesthesia, Meta-analysis, postoperative cognitive dysfunction, Postoperative cognitive dysfunction (POCD), postoperative delirium
Received: 14 Oct 2025; Accepted: 09 Dec 2025.
Copyright: © 2025 Huang and Fei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fei Fei
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