REVIEW article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
This article is part of the Research TopicPerioperative Management Strategies of Pediatric Anesthesia and Associated OutcomesView all articles
Remimazolam in Pediatric Ambulatory Anesthesia: A Critical Review and Clinical Perspective
Provisionally accepted
- Wanzhou District maternal and Child Health hospital of Chongqing, Chongqing, China
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The management of anesthesia for pediatric day surgery demands rapid onset, precise control, and predictable recovery. Remimazolam, an ultrashort-acting benzodiazepine with esterase-dependent metabolism, theoretically meets these needs. However, current pediatric evidence relies primarily on small observational studies with methodological limitations; data for infants under 2 years and long-term neurodevelopmental outcomes remain virtually absent. We conclude that while remimazolam holds promise, its use must be cautious and restricted to carefully selected scenarios until robust randomized controlled trials become available.
Keywords: Remimazolam, Pediatric day surgery, Anesthesia, Safety, Critical appraisal, pharmacokinetics, Pharmacodynamics, future perspectives
Received: 11 Oct 2025; Accepted: 01 Dec 2025.
Copyright: © 2025 Zhang, Liu, Wang, Guo, Zeng, Cui and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Kaiyun Li
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