CASE REPORT article
Front. Med.
Sec. Dermatology
Nursing management of a patient with pulmonary mucormycosis with skin damage secondary to amphotericin B colloidal dispersion: A case report
Provisionally accepted
- Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
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Introduction Mucormycosis is a catastrophic fungal infection in immunocompromised patients and has a high mortality rate. Amphotericin B colloidal dispersions has demonstrated clinical efficacy in the treatment of mucormycosis; however, there is limited literature on the management of severe skin damage secondary to the extravasation of amphotericin B colloidal dispersions. Case presentation A 36-year-old diabetic female with severe pulmonary mucormycosis developed skin damage on her left foot after 34 days of amphotericin B colloidal dispersion treatment via a peripheral vein. The medication was switched to a central vein, and nursing interventions, including silver alginate ion dressing and saline wet compress, successfully managed the injury. By day 155, the skin had fully healed with minimal residual pigmentation. Conclusion This case report presents the management of an immunocompromised patient with severe skin injury secondary to amphotericin B colloidal dispersion extravasation by bedside nurses. Relevance for Clinical Practice: This study offers an effective management strategy for skin damage from amphotericin B colloidal dispersions extravasation, emphasizing timely intervention and optimizing care for patients on prolonged or high-dose therapy.
Keywords: adverse effects, Amphotericin B, Extravasation, immunocompromised, Mucormycosis, Skin damage
Received: 12 Oct 2025; Accepted: 19 Dec 2025.
Copyright: © 2025 Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shiyao Wang
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