REVIEW article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
This article is part of the Research TopicExtracorporeal Organ Support: Innovations and Challenges in Critical CareView all 16 articles
Update of the Sequential Organ Failure Assessment Score: Current status and challenges?
Provisionally accepted
Jiafei Yu1Kangwei Sun1Yiping Zhou1Yushi Fan1Xinyun Zhang1
Heyu Chen1Lanxin Cao1Kai Zhang1
Gensheng Zhang1,2*- 1Department of Critical Care Medicine, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China
- 2Zhejiang Province Clinical Research Center for Emergency and Critical Care Medicine, Hangzhou, China
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The sequential organ failure assessment (SOFA) score has been widely used for approximately thirty years for the clinical assessment and monitoring of organ dysfunction in patients. However, advancements in medical science and clinical practice have identified several limitations of the SOFA score, underscoring the need for its revision. This paper synthesizes and summarizes the recent advances and provides a comprehensive understanding of the deficiencies of the SOFA score, which requires certain refinements. Furthermore, this work presents a scientific basis and direction for further modifications to enhance the clinical utility of the score.
Keywords: Deficiencies, Intensive Care Unit, Modifications, multiple organ dysfunction, SOFA score
Received: 27 Oct 2025; Accepted: 01 Dec 2025.
Copyright: © 2025 Yu, Sun, Zhou, Fan, Zhang, Chen, Cao, Zhang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gensheng Zhang
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