ORIGINAL RESEARCH article
Front. Med.
Sec. Translational Medicine
Effects and underlying mechanism of platelet-rich plasma gel on vaginal microecology and stump healing
Provisionally accepted
- 1Affiliated Hospital of Zunyi Medical University, Zunyi, China
- 2KweiChow Moutai Hospital, Zunyi, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Objective: To evaluate the effects and mechanism of platelet-rich plasma (PRP) gel on vaginal microecology and healing of the vaginal stump after laparoscopic hysterectomy. Methods: From December 2022 to August 2024, 100 patients who underwent laparoscopic hysterectomy in our hospital were divided into an observation group and a control group. The control group received conventional suturing, while the observation group additionally received PRP gel placement between the reflex peritoneum and vaginal stump. Vaginal stump healing, vaginal microecology, inflammatory response, and MBL and TLR4 levels were compared between groups. Results: The observation group exhibited a higher rate of grade A healing and lower rates of vaginal stump bleeding and granulation (P<0.05). One month after surgery, the observation group had more cases of cleanliness level I–II, fewer cases of level III–IV, fewer pH>4.5, and lower positive rates of sialidase activity, hydrogen peroxide abnormalities, and leukocyte esterase activity (P<0.05). The total pathogen infection rate was also reduced (P<0.05). Three days after surgery, CRP, IL-6, IL-11, IL-21, IL-2, TLR4, and MBL levels declined in both groups, with lower levels in the observation group (P<0.05). Conclusion: PRP gel can improve vaginal microecology and promote vaginal stump healing in patients undergoing laparoscopic hysterectomy, potentially through regulation of inflammatory cytokines and immune-related factors such as TLR4 and MBL. Further studies are needed to clarify mechanisms and long-term outcomes.
Keywords: Lactobacillus, Vaginal stump, Vaginal microecology, Inflammatory factors, TLR4, MBL, Laparoscopic hysterectomy
Received: 11 Nov 2025; Accepted: 03 Dec 2025.
Copyright: © 2025 Wang, Peng, Zhou, Liu, Zou and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Zhiliang Wang
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.