CASE REPORT article
Front. Med.
Sec. Nephrology
The overlap of ANCA associated vasculitis with Sjögren's syndrome in elderly male patient: A Case report and literature review
Provisionally accepted
- 1Zhejiang Chinese Medical University Affiliated Third Hospital, Hangzhou, China
- 2Tianjin Medical University, Tianjin, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is a rare disease characterized by inflammation of small vessels in various organs, usually affecting the kidneys, lungs, upper respiratory tract, skin, eyes, and peripheral nerves. The typical renal pathological manifestation is necrotizing crescentic glomerulonephritis. Sjögren's syndrome is another relatively uncommon autoimmune disorder characterized by dry eyes and dry mouth. Here, we present a case of overlap syndrome involving AAV with SS in an elderly male patient who demonstrated significant improvement following aggressive treatment with cyclophosphamide, glucocorticoids, hemodialysis, and rituximab. In addition, we also found 49 cases of overlapping syndrome of ANCA combined with SS through literature review and summarized and analyzed them.
Keywords: ANCA-associated vasculitis, csae report, Overlap syndrome, rituximab, Sjögrens syndrome
Received: 05 Aug 2025; Accepted: 09 Feb 2026.
Copyright: © 2026 Zhu, Zhu, Zhu, Jiang, Jia, Zhang, Qu and Lu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Zhongjie Qu
Keda Lu
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.