CASE REPORT article
Front. Med.
Sec. Obstetrics and Gynecology
Bevacizumab Combined with Chemotherapy Followed by PARP Inhibitor Maintenance Therapy in POLE-Mutated Primary Fallopian Tube Carcinoma: A Case of Precision Treatment in a Rare Gynecologic Malignancy
Provisionally accepted
- 1People's Liberation Army General Hospital of Southern Theatre Command, Guangzhou, China
- 2University of Nottingham Ningbo China, Ningbo, China
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Background: Primary fallopian tube carcinoma (PTC) is a rare epithelial malignancy of gynecologic origin. The adenosquamous carcinoma variant with POLEmutations is particularly uncommon, and current treatment strategies are limited by its elusive pathogenesis. Given similarities in biological behavior and clinical characteristics to ovarian cancer, PTC staging and management follow ovarian cancer guidelines. Previous studies suggest that anti-angiogenic therapy and poly (ADP-ribose) polymerase (PARP) inhibitors may be potential therapeutic options. Case Presentation: We report a case of bilateral PTC exhibiting histologic heterogeneity and a POLEmutation, complicated by pelvic recurrence with bilateral lung metastases and sigmoid colon involvement. Partial response (PR) was achieved after six cycles of albumin-bound paclitaxel plus carboplatin (nab-TC) combined with bevacizumab (Bev), followed by maintenance therapy with the PARP inhibitor niraparib. Conclusion: This case demonstrates that Bev combined with chemotherapy may be an effective first-line regimen for this rare PTC variant. Maintenance therapy with a PARP inhibitor may prolong progression-free survival.
Keywords: adenosquamous carcinoma, anti-angiogenic therapy, Fallopian tube carcinoma, niraparib, POLE mutation
Received: 01 Sep 2025; Accepted: 13 Jan 2026.
Copyright: © 2026 Cheng, Huang, Liu, shxxl4@nottingham.edu.cn and HE. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: XueQin Huang
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