CASE REPORT article
Front. Med.
Sec. Infectious Diseases: Pathogenesis and Therapy
Synergistic Eradication of Candida albicans Prosthetic Valve Endocarditis with Liposomal Amphotericin B and High-Dose Caspofungin: A Case Report
Provisionally accepted
- 1Peking University Shenzhen Hospital Department of Critical Care Medicine, Shenzhen, China
- 2Peking University Shenzhen Hospital Department of Dermatology, Shenzhen, China
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Prosthetic valve endocarditis (PVE) due to Candida albicans was diagnosed in a 58-year-old woman one year after mitral bioprosthetic replacement for severe regurgitation. The diagnosis was prompted by recurrent fever and confirmed by positive blood cultures and echocardiographic vegetations. The isolate was susceptible to amphotericin B, azoles, and echinocandins. Despite meeting surgical criteria, the patient declined reoperation. Salvage therapy with liposomal amphotericin B combined with high-dose caspofungin successfully resolved symptoms and led to vegetation regression on follow-up imaging. The patient was discharged on lifelong suppressive antifungal therapy based on susceptibility profiling.
Keywords: Antifungal Agents, Candida albicans, Echocardiography, fungal endocarditis, non-surgical treatment, Prosthetic valve endocarditis, transesophageal echocardiography
Received: 09 Oct 2025; Accepted: 12 Feb 2026.
Copyright: © 2026 Feng, Huang, Luo, Peng and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Qing Feng
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