REVIEW article
Front. Med.
Sec. Gastroenterology
This article is part of the Research TopicEmerging Therapies for Metabolic Bone DiseasesView all 5 articles
Impact of Sleeve Gastrectomy on Bone Metabolism in Obese Patients: From Mechanisms to Clinical Prevention
Provisionally accepted
- 1甘肃中医药大学第一临床医学院, 兰州市, China
- 215790871752, 兰州市, China
- 3甘肃省人民医院, 兰州市, China
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In recent years, the global incidence of obesity has continued to rise, making obesity and its associated complications a serious threat to human health. Bariatric surgery, represented by sleeve gastrectomy (SG), has emerged as a crucial intervention for the treatment of obesity and related metabolic comorbidities. However, accumulating evidence indicates that bariatric surgery exerts multiple adverse effects on bone tissue, characterized by significantly increased bone resorption, decreased bone mineral density (BMD), and a consequent elevation in fracture risk. This review summarizes the effects of SG on BMD, bone turnover markers (BTMs), and bone microarchitecture in obese individuals, and comprehensively discusses the underlying mechanisms as well as corresponding clinical prevention strategies.
Keywords: bone metabolism, bone mineral density, Bone turnover markers, Obesity, sleeve gastrectomy
Received: 19 Oct 2025; Accepted: 31 Jan 2026.
Copyright: © 2026 范, 王, 付, 朱, 盛 and 王. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: 晓鹏 王
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