CASE REPORT article
Front. Med.
Sec. Nephrology
This article is part of the Research TopicCase Reports in Pediatric Oncology: 2025View all 12 articles
A case of pediatric reninoma and literatures review
Provisionally accepted
- 1Langfang People's Hospital Hebei, Langfang, China
- 2The Second Hospital of Hebei Medical University, Shijiazhuang, China
- 3Shijiazhuang Maternal and Child Health Hospital, Shi Jia Zhuang, China
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Objective To investigate the clinical manifestations, pathological characteristics, diagnosis, treatment, and prognosis of reninoma. Methods A retrospective analysis was conducted on the clinical data of one reninoma patient admitted in 2023, supplemented by an analysis of 62 reninoma cases diagnosed and treated in China between 2016 and May 2025, as reported in the literature. Results The patient was a 10-year-old female admitted for hypertension detected during a physical examination. With normal serum potassium levels, bilateral renal vein sampling confirmed atypical reninoma. Under ultrasound guidance, radiofrequency ablation was performed on the right renal tumor, and pathological examination confirmed the diagnosis. Two years postoperatively, the patient presented again with elevated blood pressure and underwent partial right nephrectomy, after which blood pressure normalized. Reviewing the literature, among the 62 reported cases in China, 44 were typical reninoma, 16 were atypical reninoma (patients presented only with hypertension and normal serum potassium levels), and 2 were non-functional reninomas. Conclusion Young women presenting with hypertension, with or without hypokalemia, should raise suspicion for reninoma. Diagnosis requires integration of clinical presentation, imaging findings, and pathological characteristics. Curative treatment is achievable through tumor resection preserving renal units.
Keywords: Children, Hypertension, Hypokalemia, Renin - angiotensin - aldosterone system (RAS), reninoma
Received: 07 Nov 2025; Accepted: 09 Feb 2026.
Copyright: © 2026 Zhao, Yuan, Wang, Yan, Chong, Li and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yanan Zhang
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