ORIGINAL RESEARCH article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
This article is part of the Research TopicData Science in Anesthesiology and Intensive CareView all 14 articles
Association between the Use of β-Adrenergic Receptor Blockers and All-cause Mortality in Sepsis-Associated Rhabdomyolysis Syndrome: A Cohort Study
Provisionally accepted
- Ningbo Medical Centre Lihuili Hospital, Ningbo, China
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Background: To assess the association between the use of β-blockers and all-cause mortality in Sepsis-associated Rhabdomyolysis (SAR). Methods: This retrospective cohort study involves adults with SAR. Study variables were extracted from the MIMIC-IV (Medical Information Mart for Intensive Care-IV) database. Propensity score matching (PSM) was conducted at a 1:1 ratio to analyze the association between the use of β-blockers and in-hospital mortality in SAR. Multivariable analysis was employed to adjust for confounding factors, while sensitivity analysis and subgroup analysis were conducted to demonstrate the robustness of the results. Results: This study involved pre-matched and propensity score-matched cohorts comprising 1194 and 584 patients, respectively. Through propensity score matching (PSM) analysis, this study observed a notable difference in in-hospital mortality rates. Importantly, the utilization of β-blockers was found to be significantly associated with lower in-hospital all-cause mortality. Furthermore, sensitivity analyses conducted on the entire cohort, as well as cohorts excluding patients with specific comorbidities, consistently demonstrated a significant association between β-blocker usage and lower in-hospital mortality. Subgroup analyses further underscored the robustness of the findings. Conclusions: The use of β-blockers was associated with lower mortality in patients with SAR. However, prospective studies are needed to validate this finding.
Keywords: Mimic, Mortality, Propensity score matching, Sepsis-Associated Rhabdomyolysis, β-blockers
Received: 11 Nov 2025; Accepted: 26 Jan 2026.
Copyright: © 2026 Yi, Huang, Zheng, Shen, Jin, Dai and Jin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuhong Jin
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