ORIGINAL RESEARCH article
Front. Med.
Sec. Family Medicine and Primary Care
This article is part of the Research TopicUnravelling the Genetic and Environmental Factors in Early-Life Development and Future Disease RiskView all 6 articles
Analysis of influencing factors of congenital heart disease in children in a region based on case control
Provisionally accepted
- 1Affiliated Hospital of Southwest Medical University, Luzhou, China
- 2Sichuan Provincial Clinical Medical Center for Birth Defects, Luzhou, China
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The purpose of the current research was to analyze the influencing factors of congenital heart disease (CHD) in children based on case control. From January 2020 to January 2022, sixty CHD children under 6 years old admitted to Affiliated Hospital of Southwest Medical University were selected as the research group. Another 60 children with the same age and sex who underwent physical examination in our hospital without CHD were selected as the control group. The disease classification of children with CHD was screened, and the related influencing factors were analyzed. Among 60 children with CHD, atrial septal defect was the highest in the single heart defect, accounting for 36.67%, followed by ventricular septal defect (25.00%), patent ductus arteriosus (11.67%), pulmonary stenosis (6.67%), tetralogy of Fallot (5.00%) and aortic stenosis (1.67%). The rate of combined with 2 or 3 heart defects were 10.00% and 3.33%, respectively. The family history of CHD, history of viral infection in early pregnancy, and history of medication in early pregnancy were independent risk factors for CHD. Collectively, the family history of CHD, maternal history of viral infection in early pregnancy and drug use in early pregnancy are independent risk factors for CHD.
Keywords: Children, congenital heart disease, Influencing factors, risk factor, viral infection
Received: 13 Nov 2025; Accepted: 16 Feb 2026.
Copyright: © 2026 Zhang, Pan and Yang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Changling Zhang
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