ORIGINAL RESEARCH article
Front. Med.
Sec. Dermatology
This article is part of the Research TopicProgress in Pathogenesis, Diagnosis and Treatment of Inflammatory DermatosisView all 4 articles
Evaluation of the chemerin levels in the pathogenesis of psoriasis The role of chemerin in the pathogenesis of psoriasis
Provisionally accepted
Mateusz Matwiejuk*
Agnieszka Kulczynska-Przybik
Bartłomiej Łukaszuk
Hanna MyśliwiecPiotr MyśliwiecAdrian Chabowski
Barbara MroczkoIwona Flisiak- Medical University of Bialystok, Bialystok, Poland
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Psoriasis is a complex, chronic, inflammatory condition which affects skin, nails and joints. In our study, we enrolled fifty patients with psoriasis and twenty-eight healthy individuals. Serum samples were collected both from the psoriatic patients (study group) and patients with an inguinal hernia (control group). The level of chemerin in the serum was measured by enzyme-linked immunosorbent assay. In the current research we noticed that serum chemerin concentration was significantly higher in the patients suffering from psoriasis in comparison to the controls. Importantly, we observed a positive, statistically significant correlation between the serum chemerin levels and C-reactive protein, as well as chemerin levels and platelets PLT in the serum of patients affected by psoriasis. However, we did not observe a significant correlation between chemerin level and the Psoriasis Area and Severity Index score. To sum up, our results revealed that chemerin levels vary significantly in the serum of patients with psoriasis in contrast to the control group.
Keywords: chemerin, Inflammation, protein, Psoriasis, Skin Diseases
Received: 17 Nov 2025; Accepted: 30 Jan 2026.
Copyright: © 2026 Matwiejuk, Kulczynska-Przybik, Łukaszuk, Myśliwiec, Myśliwiec, Chabowski, Mroczko and Flisiak. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Mateusz Matwiejuk
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