SYSTEMATIC REVIEW article
Front. Med.
Sec. Dermatology
This article is part of the Research TopicCutaneous Oncology and Management of Adverse EventsView all 3 articles
Contemporary Management of Treatment-Related Dermatologic Toxicities in Gynecologic Cancers: A Systematic Review Based on Evidence from 2021 to 2025
Provisionally accepted
- 1Shenzhen Luohu People’s Hospital, Shenzhen, China
- 2Shenzhen Luohu Hospital Group Luohu People's Hospital, Shenzhen, China
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Gynecologic cancers are often treated with chemo, radio, and targeted therapies, all effective but causing lots of skin side effects that really decrease quality of life and how willing you are to keep going with the treatment. This current systematic review puts together the newest evidence found till 2025 about treatment-caused skin damage in women's cancers, what the patients can see or feel, what is going on inside their body that nobody can see, things that make it happen more often, and how to deal with it. Areas that matter: subclinical skin damage – early, mostly symptomless changes caused by medicines like paclitaxel; skin issues from radiotherapy; and bad skin effects of new targeted treatment. Review stresses on individual intervention plans and multidisciplinary care models to address these toxicities. And it goes into some of the more innovative technologies, like 3D printed radiotherapy devices, and how they might be able to prevent and mitigate dermatologic toxicities. To give doctors the best information to help make things better for people who get skin problems from gynecological cancer treatment, so that more people can feel better about their treatment and health.
Keywords: 3D printed radiotherapy devices, chemotherapy, gynecologic cancer, Paclitaxel, Radiotherapy, Skin Management, Skin toxicity, subclinical skin damage
Received: 21 Nov 2025; Accepted: 12 Jan 2026.
Copyright: © 2026 Wang, Hou, Wang, Liu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Chu Liu
Shida Xu
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