CASE REPORT article
Front. Med.
Sec. Dermatology
Successful Management of DPP-4 Inhibitor-Induced Bullous Pemphigoid with Stapokibart Injection in an Elderly Diabetic Patient: A Case Report
Man Yu 1
Shue Tian 2
Fanlin Meng 1
1. Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China
2. Deyang Hospital Affiliated Hospital of Chengdu University of Traditional Chinese Medicine, Deyang China., Deyang, China
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Abstract
Dipeptidyl peptidase-4 (DPP-4) inhibitors, such as linagliptin, have been implicated in inducing bullous pemphigoid (BP) in elderly diabetic patients. Stapokibart is a humanized monoclonal antibody targeting interleukin-4 receptor subunit alpha (IL-4Rα), primarily used for atopic dermatitis, with no prior reports of its application in BP. This article describes a case of DPP-4 inhibitor-induced bullous pemphigoid treated with Stapokibart. Following Stapokibart therapy, the patient exhibited complete resolution of skin lesions, significant improvement in quality of life, and no adverse reactions. This case suggests that Stapokibart may be an effective treatment for bullous pemphigoid induced by DPP-4 inhibitors.
Summary
Keywords
Bullous pemphigoid, diabetes, dipeptidyl peptidase-4 inhibitors, Linagliptin, Stapokibart
Received
27 November 2025
Accepted
18 February 2026
Copyright
© 2026 Yu, Tian and Meng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Shue Tian; Fanlin Meng
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