ORIGINAL RESEARCH article
Front. Med.
Sec. Dermatology
Experience in the management of real-world patients with chronic prurigo nodularis within a Dermatology setting. Results from the ECOSPIN Spanish survey-based study
Ignasi Figueras Nart 1,2
Rafael Ortiz Castillo 3
Esther Serra Baldrich 4
1. Hospital Universitari de Bellvitge, L'Hospitalet de Llobregat, Spain
2. University of Barcelona, Barcelona, Spain
3. Sanofi SA, Madrid, Spain
4. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
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Abstract
Background: Chronic prurigo nodularis (CPN), is a chronic, inflammatory, highly pruritic skin disease with significant burden, but the epidemiological data available is still very limited. This study aims to describe the sociodemographic and clinical profile of real-world patients with CPN in Dermatology consultations in Spain. Methods: ECOSPIN was a Spanish, observational, ecological, survey-based study with aggregated data obtained from the experience and routine clinical practice of 39 dermatologists. Results: According to the dermatologists, a mean of 29.1% patients with CPN were aged 51-60 and most were women (61%). A mean of 97.9% experienced itching, with frequent comorbidities: atopic dermatitis (41.1%), hypertension (32.1%), anxiety (57.4%), and depression (43.6%). Dermatologists considered the CPN etiology dermatological in a mean of 56.5% of cases. The main treatments were topical corticosteroids and calcineurin inhibitors (91.2%). For systemic therapy, dupilumab was the most used (51.8%) and rated as the most effective. The most relevant treatment goal was rapid itch elimination or reduction, while managing comorbidities was important for minimizing healthcare resource utilization, based on the dermatologists' experience. Conclusions: The study highlighted unmet needs and the high burden of CPN, emphasizing the need for multidisciplinary and individualized treatment approaches.
Summary
Keywords
chronic prurigo nodularis, Real-world, Skin Diseases, Survey, Treatment
Received
16 December 2025
Accepted
19 February 2026
Copyright
© 2026 Figueras Nart, Ortiz Castillo and Serra Baldrich. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Ignasi Figueras Nart
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