ORIGINAL RESEARCH article
Front. Med.
Sec. Ophthalmology
Sustained Intraocular Pressure Lowering from Suprachoroidal Injection of a Latanoprost Lipid Nanoparticle Delivery System in the Rabbit
Phey Feng Lo 1,2
Sai Bo Bo Tun 2
Joanna Marie Fianza Busoy 2
Shamira Perera 2,1
Veluchamy A. Barathi 2,3
Tina T Wong 2,1,3
1. Singapore National Eye Center, Singapore, Singapore
2. Singapore Eye Research Institute, Singapore, Singapore
3. Duke-NUS Medical School, Singapore, Singapore
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Abstract
Background: Current treatments for glaucoma to lower intraocular pressure (IOP) are dependent on patient adherence and bioavailability after bypassing ocular barriers. Our study investigated the safety and efficacy of a liposomal nanocarrier for sustained release of latanoprost injected into the suprachoroidal space in the rabbit eye. Methods: Dutch-Belt rabbits were injected with a single dose of 150µl of 2mg/ml of liposomal latanoprost formulation into the suprachoroidal space. The eyes were clinically monitored for adverse events and the IOP recorded. Results: IOP reduced from baseline to 8 hours post liposomal latanoprost injection by 28% (5.1 ± 2.12mmHg), reaching a maximum of 40% (7.2 ± 1.9mmHg) at Day 5. Low IOP was sustained until Day 56 returning to baseline at Day 90. Safety assessment of the eyes showed no adverse events and good tolerability of the drug. Conclusions: A single dose of liposomal latanoprost into the suprachoroidal space can lower the IOP for up to 56 days making it a promising therapeutic agent for sustained delivery drugs to the suprachoroidal space.
Summary
Keywords
animal model, Glaucoma, Liposomal latanoprost, Nanoparticle drug delivery system, Suprachoroidal space, Sustained drug delivery
Received
28 December 2025
Accepted
20 February 2026
Copyright
© 2026 Lo, Tun, Busoy, Perera, Barathi and Wong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Tina T Wong
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.