CASE REPORT article
Front. Med.
Sec. Hepatobiliary Diseases
Intrahepatic Ectopic Atypical Parathyroid Tumor Causing Primary Hyperparathyroidism: A Case Report
Yuanzheng Ding 1,2
Weichao Li 2,1
Junkai Li 2
Zhiwei Zhang 2,1
Yuli Gao 2,1
Bo Yuan 2,1
Caixia Cheng 2
Jing Liu 2
1. Shanxi Medical University, Taiyuan, China
2. First Hospital of Shanxi Medical University, Taiyuan, China
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Abstract
Abstract Primary hyperparathyroidism (PHPT) most commonly arises from cervical parathyroid pathology, with ectopic disease representing a rare entity. We report a case of PHPT diagnosed during fracture workup in a female patient who manifested persistent hypercalcemia and elevated parathyroid hormone (PTH) despite two prior cervical explorations. Cross-sectional and functional imaging, including PET/CT, localized a PTH-secreting hepatic lesion, which was confirmed by ultrasound-guided biopsy. Laparoscopic resection of the intrahepatic tumor resulted in prompt biochemical normalization. Histopathology confirmed an intrahepatic ectopic atypical parathyroid adenoma. This case underscores that refractory PHPT with persistent biochemical derangements following conventional cervical surgery should prompt consideration of rare ectopic parathyroid neoplasms with atypical histologic features.
Summary
Keywords
atypical parathyroid tumor, case report, Ectopic parathyroid tumor, Liver, primary hyperparathyroidism
Received
05 January 2026
Accepted
16 February 2026
Copyright
© 2026 Ding, Li, Li, Zhang, Gao, Yuan, Cheng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Caixia Cheng; Jing Liu
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