CLINICAL TRIAL article
Front. Med.
Sec. Intensive Care Medicine and Anesthesiology
Effects of Different Doses of Alfentanil on Tracheal Intubation Stress Responses in Ambulatory Hysteroscopic Surgery: A Randomized, Double-Blind, Clinical Comparative Study
Xi Zha
Xia Ju
Jinjuan Duan
Siqi Xu
Anqing Municipal Hospital, Anqing, China
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Abstract
Background: This randomized, double-blind, clinical comparative study aims to compare the tracheal intubation stress responses of different doses of alfentanil in anesthesia induction for ambulatory hysteroscopic surgery, as well as their impact on the quality of early postoperative recovery. Results: The levels of plasma NE and E in group AL were significantly higher than that in group F at T2, the levels of plasma NE and E in group AM were significantly lower than that in group AL at T2 ~ T3, and the levels of plasma NE and E in group AH were significantly lower than that in group AL and group F at T2 ~ T3 (p < 0.05). Compared with group F, MAP and HR in group AL were significantly higher at T2 (p < 0.05). Compared with group AL, MAP and HR in group AM were significantly lower at T1 ~ T3 (p < 0.05), the incidence of hypertension and tachycardia from anesthesia induction to 5 min after tracheal intubation was significantly lower in group AM (p < 0.05). Compared with group AL and group F, MAP and HR in group AH were significantly lower at T1 ~ T3 (p < 0.05), the incidence of hypotension and bradycardia was significantly higher from anesthesia induction to 5 min after tracheal intubation, and the incidence of hypertension and tachycardia was significantly lower (p < 0.05). The NRS pain scores at the time of extubation in group AL were significantly higher than in groups AM, AH, and F (p < 0.05). Conclusions: In ambulatory hysteroscopic surgery, intravenous 30 μg/kg and 40 μg/kg alfentanil inhibited the stress reaction caused by tracheal intubation, alleviated hemodynamic fluctuations, and decreased the intensity of postoperative pain. However, 40 μg/kg alfentanil significantly increased the incidence of hypotension and bradycardia from anesthesia induction to 5 min after tracheal intubation. Therefore, 30 μg/kg alfentanil may be more suitable for the application of ambulatory hysteroscopic surgery.
Summary
Keywords
adverse effects, Alfentanil, Hemodynamics, Hysteroscopic surgery, Pain, stress response
Received
15 January 2026
Accepted
10 February 2026
Copyright
© 2026 Zha, Ju, Duan and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Xia Ju
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