ORIGINAL RESEARCH article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1591644
This article is part of the Research TopicClinical Molecular Biological Characteristics of Malignant TumorsView all articles
Clinicopathologic and Proteomic Characteristics of Low-Grade Undifferentiated Spindle Cell Sarcoma
Provisionally accepted
- The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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Introduction: Undifferentiated spindle cell sarcoma (USCS) is a rare and heterogeneous group without specific diagnostic, prognostic, or predictive markers. The clinicopathologic and proteomic characteristics of USCS remain largely unknown.Methods: Between 2008 and 2024, we collected 14 low-grade USCSs and 104 undifferentiated pleomorphic sarcomas (UPSs). We conducted a comprehensive mass spectrometry (MS) proteomic analysis on USCSs and compared the clinicopathologic characteristics of low-grade USCSs and UPSs. More than 5600 proteins could be identified.Results: Low-grade USCSs had 353 up-regulated and 500 down-regulated proteins compared to corresponding normal tissue. PHRF1, DIDO1, RAPH1, GGT7, and PHF14 exhibited overexpression in low-grade USCSs, whereas SERPINF2, TMEM40, FYCO1, COL2A1, and NPNT demonstrated low expression. The KEGG pathway enrichment analysis revealed that most of the enriched pathways in low-grade USCS were related to various amino acid and lipid metabolic. Correlating significantly changed proteins with their targeting medications revealed novel therapy options for low-grade USCSs. Furthermore, in comparison to UPSs, our findings indicate that low-grade USCSs may exhibit smaller sizes and a lower rate of distant metastasis. In summary, to the best of our knowledge, this is the first in-depth proteomic analysis to demonstrate a comprehensive investigation of the clinicopathological and proteomic characteristics of low-grade USCSs.We initially elucidated the characteristics of differential proteins, the pathways enriched, and their possible drug targets in low-grade USCSs. Data are available via ProteomeXchange with identifier PXD061644.
Keywords: undifferentiated spindle sarcoma, Soft tissue tumor, proteomic characteristic, Pathology, biomarker, diagnosis, Molecular diagnosis
Received: 11 Mar 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Wei, Li, He, Li, Chen, Shi and Han. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Huijuan Shi, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Anjia Han, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
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