ORIGINAL RESEARCH article

Front. Mol. Biosci.

Sec. Molecular Diagnostics and Therapeutics

Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1600626

This article is part of the Research TopicExploring the Correlation and Heterogeneity Between Acute and Chronic Diseases: Diagnostic and Therapeutic PerspectivesView all articles

A LODDS-based nomogram for overall and cancer-specific survival in stage III-IV gastric signet ring cell carcinoma

Provisionally accepted
Cenzhu  WangCenzhu Wang1Ying  FangYing Fang2Yuhan  ZhangYuhan Zhang1Shuhan  FengShuhan Feng3Rui  HouRui Hou1Hanfang  FanHanfang Fan1Zeyu  WangZeyu Wang1Lei  LiuLei Liu3Junli  DingJunli Ding1Junying  XuJunying Xu1*
  • 1Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, China
  • 2Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu Province, China
  • 3Yixing People's Hospital, Yixing, Jiangsu, China

The final, formatted version of the article will be published soon.

Objective: Gastric cancer is a serious human chronic disease. The gastric signet ring cell carcinoma (GSRCC) is the most-dangerous subtype with several acute complications, including gastrointestinal hemorrhage, gastric perforation, pyloric obstruction and so on. This study aimed to compare the predictive efficiency of positive lymph nodes (PLN) and log odds of positive lymph nodes (LODDS) for survival and to establish a LODDS-based nomogram model in stage III-IV GSRCC. Methods: Stage III-IV GSRCC patients were acquired between 2015 and 2019 from SEER dataset and the affiliated Yixing hospital of jiangsu university, serving as training and validation datasets respectively. The X-tile software was used to identify cut-off values while their relationship with clinical features was explored by chi-square test. The Kaplan-Meier analysis was applied for survival curve while cox regression analysis was performed for independent risk factors. The nomogram model was built with ROC and calibration curves for verification. Results: A total of 585 stage III-IV GSRCC patients were included in this study with 536 patients for training and 49 patients for validation. The LODDS showed better predictive efficiency for overall survival (OS) and cancer specific survival (CSS) than PLN. The LODDS, M stage and chemotherapy status were independent factors for both OS and CSS, with LODDS contribution accounting for 31.47% in OS and 30.39% in CSS. A LODDS-based nomogram was built with accurate efficiency in stage III-IV GSRCC. The 1-year, 2-year, 3-year OS area under curve (AUC) values were 0.755, 0.795, 0.759 for internal and 0.776, 0.756, 0.816 for external verification while 1-year, 2-year, 3-year CSS AUC values were 0.745, 0.803, 0.770 for internal and 0.796, 0.762, 0.820 for external verification. Conclusions: LODDS is an independent risk factor in stage III-IV GSRCC. The LODDS-based nomogram model showed excellent predictive efficiency, providing a novel insight for early diagnosis and precise therapies of stage III-IV GSRCC.

Keywords: GSRCC, Stage III-IV, PLN, LODDS, nomogram

Received: 26 Mar 2025; Accepted: 28 Apr 2025.

Copyright: © 2025 Wang, Fang, Zhang, Feng, Hou, Fan, Wang, Liu, Ding and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Junying Xu, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, China

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