REVIEW article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1603392
This article is part of the Research TopicChallenges and Opportunities in Tumor MetabolomicsView all 7 articles
Review of Research Progress in Sepsis-Associated Acute Kidney Injury
Provisionally accepted
- 1Department of Health Management, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
- 2Department of Emergency Medicine, ShengJing Hospital of China Medical University, Shenyang, Liaoning Province, China
- 3Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
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Sepsis-associated acute kidney injury (SAAKI) poses a significant challenge in critical care medicine, characterized by high morbidity and mortality rates and often leading to chronic kidney disease (CKD). This article provides a comprehensive overview of the pathophysiological mechanisms, diagnostic advancements, therapeutic strategies, and prognostic studies of SAAKI. In terms of pathophysiological mechanisms, research has shifted from the traditional renal ischemia-centric view to a multidimensional interplay involving microcirculatory disturbances, immune metabolic disorders, and programmed cell death. Regarding diagnosis, traditional Kidney Disease: Improving Global Outcomes (KDIGO) criteria exhibit limitations, whereas novel biomarkers and imaging techniques offer new avenues for early diagnosis. Therapeutic strategies encompass early intervention, hemodynamic management, renal replacement therapy, and targeted therapies; however, controversy persists regarding the optimal timing and methods of their initiation. Prognostic studies focus on the mechanisms underlying the transition from SAAKI to CKD and corresponding preventive strategies. Future research should bridge the gap between animal models and human pathology and explore the potential of multi-omics technologies and artificial intelligence in optimizing management.
Keywords: Sepsis, acute kidney injury (AKI), Pathophysiological mechanisms, diagnosis, Treatment, prognosis P2X7 Receptor Rat Model, Fecal Peritonitis Inhibition Decreased Renal IL-1β Levels
Received: 31 Mar 2025; Accepted: 30 Apr 2025.
Copyright: © 2025 Nian, Tao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haiyi Zhang, Sheng Jing Hospital Affiliated, China Medical University, Shenyang, China
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