ORIGINAL RESEARCH article
Front. Mol. Biosci.
Sec. Molecular Diagnostics and Therapeutics
Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1607352
Expression and clinical significance of S100A8/9 in adults with secondary phagocytic lymphohistiocytosis
Provisionally accepted
- First Affiliated Hospital, Nanjing Medical University, Nanjing, China
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The study aimed to investigate the diagnostic and prognostic value of serum S100A8/9 levels with sHLHa, a high-mortality multiorgan inflammatory syndrome 2 with no reliable clinical biomarkers, where calreticulin's role is unclear. This was a study of 67 newly diagnosed sHLHa patients. 48 patients met criteria and were analyzed. ELISA detected S100A8/9 levels in patients and controls. The optimal classification threshold for S100A8/9 was determined to be 2.44 µg/mL by restricted cubic spline (RCS) curve analysis. Patients were categorized. Correlations, diagnostic efficacy, survival differences, and prognosis impacts were analyzed. Serum S100A8/9 levels in sHLHa patients were greater than in healthy controls. Various analyses showed its diagnostic and prognostic value. ANC<1.0x10 9 /L and high S100A8/9 expression group were independent risk factors for poor prognosis in patients with sHLHa. It's correlated with liver function indicators and HScore. This study evaluates S100A8/9 in sHLHa diagnosis and prognosis. S100A8/9 levels are useful for differentiating patients, providing etiologic and survival info. They show a nonlinear positive correlation with survival and a threshold effect. Serum S100A8/9 levels offer potential biomarkers, and further studies are needed.
Keywords: phagocytic lymphohistiocytosis, S100A8/9, RCS, diagnosis, prognosis
Received: 05 May 2025; Accepted: 27 Jun 2025.
Copyright: © 2025 Fang, Gao, Duan, Wang, Tian, Xu, Shu, Yin and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Guangli Yin, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
Hongxia Qiu, First Affiliated Hospital, Nanjing Medical University, Nanjing, China
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