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REVIEW article

Front. Mol. Biosci.

Sec. RNA Networks and Biology

Volume 12 - 2025 | doi: 10.3389/fmolb.2025.1616221

This article is part of the Research TopicExploring miRNA Roles in Cancer Pathogenesis and Treatment, Volume IIIView all 3 articles

MicroRNAs at the crossroad of cancer therapeutics: Insights from WNT signaling & flavonoids

Provisionally accepted
Akanksha GuptaAkanksha Gupta1Arpit MehrotraArpit Mehrotra2Abhilasha SoodAbhilasha Sood2Bunty SharmaBunty Sharma3Vikas YadavVikas Yadav4Ginpreet KaurGinpreet Kaur1Katrin SakKatrin Sak5Shakti SatapathyShakti Satapathy4*Hardeep Singh TuliHardeep Singh Tuli6
  • 1Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM's Narsee Monjee Institute of Management Studies, Mumbai, Maharashtra, India
  • 2Department of Allied Health Sciences, Chitkara School of Health Sciences, Chitkara University, Chandigarh, India
  • 3Department of Biotechnology, Graphic Era (Deemed to Be University), Dehradun, India
  • 4Cell and Experimental Pathology, Department of Translational Medicine, Lund University, Malmö, Sweden
  • 5NGO Praeventio, 50407, Tartu, Estonia
  • 6Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Ambala, India

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MicroRNAs (miRNAs) are pivotal post-transcriptional regulators that orchestrate gene expression programs governing cancer initiation, progression, metastasis, and therapeutic resistance. Among their many targets, the WNT signaling pathway, a key driver of malignancy, is tightly controlled by miRNAs, forming intricate feedback loops that shape tumor behavior. Concurrently, flavonoids, naturally occurring plant-derived polyphenols, are emerging as promising anticancer agents that can modulate both WNT signaling and miRNA expression. This review highlights miRNAs as the central regulators of oncogenic signaling, focusing on their dualistic role in cancer biology and their modulation by flavonoids. We explore the mechanistic frameworks underpinning miRNA-WNT interactions and the therapeutic potential of flavonoid-mediated miRNA reprogramming for precision miRNA targeting. Unraveling this regulatory axis offers a promising avenue for developing multi-targeted therapies and personalized cancer treatment strategies.

Keywords: Wnt signaling, microRNA, Cancer, Flavonoids, Apoptosis, metastasis

Received: 22 Apr 2025; Accepted: 25 Jul 2025.

Copyright: © 2025 Gupta, Mehrotra, Sood, Sharma, Yadav, Kaur, Sak, Satapathy and Tuli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Shakti Satapathy, Cell and Experimental Pathology, Department of Translational Medicine, Lund University, Malmö, Sweden

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material